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FCHO1560−571 peptide, a PKB kinase motif, inhibits tumor progression
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Sungjin | - |
dc.contributor.author | Hong, Youngeun | - |
dc.contributor.author | Lee, Soomin | - |
dc.contributor.author | Lee, Ah Young | - |
dc.contributor.author | Tran, Quangdon | - |
dc.contributor.author | Lee, Hyunji | - |
dc.contributor.author | Kim, Minhee | - |
dc.contributor.author | Park, Jisoo | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.contributor.author | Park, Jongsun | - |
dc.date.accessioned | 2021-01-31T08:39:13Z | - |
dc.date.available | 2021-01-31T08:39:13Z | - |
dc.date.created | 2020-11-17 | - |
dc.date.created | 2020-11-17 | - |
dc.date.issued | 2020-07 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications, Vol.528 No.3, pp.478-484 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | 116386 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172322 | - |
dc.description.abstract | Background: Cell division is regulated by protein kinase B (PKB)-mediated FCH domain only 1 (FCHO1) phosphorylation. Methods: FCHO1560-571, a synthetic water-soluble peptide, was generated from the PKB substrate motif 560PPRRLRSRKVSC571 found in the human FCHO1 protein. Results: In this study, we found that in vitro FCHO1560-571 inhibits cell proliferation via PKB/ERK/SMAD4 pathways in KRAS-mutated A549 lung cancer cells. In addition, FCHO1560-571, at effective doses of 15 and 30 mg/kg, significantly suppressed tumor growth and decreased the size and weight of tumors in A549xenograft mice. Conclusion: These results suggest that the FCHO1560-571 peptide could be a potential therapy for lung cancer. (C) 2020 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | FCHO1560−571 peptide, a PKB kinase motif, inhibits tumor progression | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.1016/j.bbrc.2020.05.173 | - |
dc.citation.journaltitle | Biochemical and Biophysical Research Communications | - |
dc.identifier.wosid | 000541789500012 | - |
dc.identifier.scopusid | 2-s2.0-85085698703 | - |
dc.citation.endpage | 484 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 478 | - |
dc.citation.volume | 528 | - |
dc.identifier.sci | 000541789500012 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | DOMAIN | - |
dc.subject.keywordAuthor | Cell-penetrating peptide | - |
dc.subject.keywordAuthor | Water-soluble peptide | - |
dc.subject.keywordAuthor | FCHO1 | - |
dc.subject.keywordAuthor | PKB | - |
dc.subject.keywordAuthor | SMAD4 | - |
dc.subject.keywordAuthor | Lung cancer | - |
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