Publications
Detailed Information
GOLGA2 loss causes fibrosis with autophagy in the mouse lung and liver
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Sungjin | - |
dc.contributor.author | Kim, Sanghwa | - |
dc.contributor.author | Kim, Min Jung | - |
dc.contributor.author | Hong, Youngeun | - |
dc.contributor.author | Lee, Ah Young | - |
dc.contributor.author | Lee, Hyunji | - |
dc.contributor.author | Tran, Quangdon | - |
dc.contributor.author | Kim, Minhee | - |
dc.contributor.author | Cho, Hyeonjeong | - |
dc.contributor.author | Park, Jisoo | - |
dc.contributor.author | Kim, Kwang Pyo | - |
dc.contributor.author | Park, Jongsun | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.date.accessioned | 2021-01-31T08:39:17Z | - |
dc.date.available | 2021-01-31T08:39:17Z | - |
dc.date.created | 2019-07-08 | - |
dc.date.issued | 2018-01 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications, Vol.495 No.1, pp.594-600 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | 78005 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172323 | - |
dc.description.abstract | Autophagy is a biological recycling process via the self-digestion of organelles, proteins, and lipids for energy-consuming differentiation and homeostasis. The Golgi serves as a donor of the double-membraned phagophore for autophagosome assembly. In addition, recent studies have demonstrated that pulmonary and hepatic fibrosis is accompanied by autophagy. However, the relationships among Golgi function, autophagy, and fibrosis are unclear. Here, we show that the deletion of GOLGA2, encoding a cis-Golgi protein, induces autophagy with Golgi disruption. The induction of autophagy leads to fibrosis along with the reduction of subcellular lipid storage (lipid droplets and lamellar bodies) by autophagy in the lung and liver. GOLGA2 knockout mice clearly demonstrated fibrosis features such as autophagy-activated cells, densely packed hepatocytes, increase of alveolar macrophages, and decrease of alveolar surfactant lipids (dipalmitoylphosphatidylcholine). Therefore, we confirmed the associations among Golgi function, fibrosis, and autophagy. Moreover, GOLGA2 knockout mice may be a potentially valuable animal model for studying autophagy-induced fibrosis. (C) 2017 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | GOLGA2 loss causes fibrosis with autophagy in the mouse lung and liver | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.1016/j.bbrc.2017.11.049 | - |
dc.citation.journaltitle | Biochemical and Biophysical Research Communications | - |
dc.identifier.wosid | 000423897600091 | - |
dc.identifier.scopusid | 2-s2.0-85035099311 | - |
dc.citation.endpage | 600 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 594 | - |
dc.citation.volume | 495 | - |
dc.identifier.sci | 000423897600091 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | HEPATIC STELLATE CELLS | - |
dc.subject.keywordPlus | PULMONARY SURFACTANT | - |
dc.subject.keywordPlus | LAMELLAR BODIES | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | SECRETION | - |
dc.subject.keywordPlus | STORAGE | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordAuthor | GOLGA2 knockout mice | - |
dc.subject.keywordAuthor | Golgi disruption | - |
dc.subject.keywordAuthor | Autophagy | - |
dc.subject.keywordAuthor | Lung fibrosis | - |
dc.subject.keywordAuthor | Liver fibrosis | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.