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Exposure to cigarette smoke disturbs adipokines secretion causing intercellular damage and insulin resistance in high fructose diet induced metabolic disorder mice

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dc.contributor.authorKim, Sang Wha-
dc.contributor.authorLee, Ah Young-
dc.contributor.authorKim, Hyeon-Jeong-
dc.contributor.authorHong, Seong-Ho-
dc.contributor.authorGo, Ryeo-Eun-
dc.contributor.authorChoi, Kyung-Chul-
dc.contributor.authorKang, Kyung Sun-
dc.contributor.authorCho, Myung-Haing-
dc.date.accessioned2021-01-31T08:39:21Z-
dc.date.available2021-01-31T08:39:21Z-
dc.date.issued2017-12-
dc.identifier.citationBiochemical and Biophysical Research Communications, Vol.494 No.3-4, pp.648-655-
dc.identifier.issn0006-291X-
dc.identifier.other42919-
dc.identifier.urihttps://hdl.handle.net/10371/172324-
dc.description.abstractA large amount of fructose intake along with smoking is associated with increased incidence of diseases linked to metabolic syndrome. More research is necessary to understand the complex mechanism that ultimately results in metabolic syndrome and the effect, if any, of high fructose dietary intake and smoking on individual health. In this study, we investigated changes in ER-Golgi network and disturbance to secretion of adipokines induced by cigarette smoking (CS) and excess fructose intake and their contribution to the disruption of metabolic homeostasis. We used high fructose-induced metabolic disorder mice model by feeding them with high fructose diet for 8 weeks. For CS exposure experiment, these mice were exposed to CS for 28 days according to OECD guideline 412. Our results clearly showed that the immune system was suppressed and ER stress was induced in mice with exposure to CS and fed with high fructose. Furthermore, their concentrations of adipokines including leptin and adiponectin were aberrant. Such alteration in secretion of adipokines could cause insulin resistance which may lead to the development of type 2 diabetes. (C) 2017 Elsevier Inc. All rights reserved.-
dc.subjectCigarette smoke-
dc.subjectHigh fructose diet-
dc.subjectOrganelle damage-
dc.subjectER stress-
dc.subjectAdipokines-
dc.subjectInsulin resistance-
dc.titleExposure to cigarette smoke disturbs adipokines secretion causing intercellular damage and insulin resistance in high fructose diet induced metabolic disorder mice-
dc.typeArticle-
dc.contributor.AlternativeAuthor조명행-
dc.identifier.doi10.1016/j.bbrc.2017.10.121-
dc.citation.journaltitleBiochemical and Biophysical Research Communications-
dc.identifier.scopusid2-s2.0-85032891585-
dc.citation.endpage655-
dc.citation.number3-4-
dc.citation.startpage648-
dc.citation.volume494-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0006291X17320995?via%3Dihub-
dc.identifier.rimsid42919-
dc.identifier.sci000416393300032-
dc.contributor.affiliatedAuthorCho, Myung-Haing-
Appears in Collections:
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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