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Efficient gene delivery using chitosan-polyethylenimine hybrid systems

Cited 35 time in Web of Science Cited 41 time in Scopus
Authors
Jiang, Hu-Lin; Kim, Tae-Hee; Kim, You-Kyoung; Park, In-Young; Cho, Myung-Haing; Cho, Chong-Su
Issue Date
2008-06
Citation
Biomedical Materials (Bristol), Vol.3 No.2
Abstract
Chitosan and chitosan derivatives have been investigated as non-viral vectors because they have several advantages, such as biocompatibility, biodegradability, low cytotoxicity and low immunogenicity. However, low transfection efficiency and low cell specificity must be solved for their use in clinical trials. In this paper, chitosan-polyethylenimine (PEI) hybrid systems such as chitosan/PEI blend and chitosan-graft-PEI are described for efficient gene delivery because the PEI has high transfection efficiency owing to a proton sponge effect and chitosan has biocompatibility. Also, hepatocyte specificity of the galactosylated chitosan is explained after combination with PEI.
ISSN
1748-6041
URI
https://hdl.handle.net/10371/172346
DOI
https://doi.org/10.1088/1748-6041/3/2/025013
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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