S-Space College of Veterinary Medicine (수의과대학) Dept. of Veterinary Medicine (수의학과) Journal Papers (저널논문_수의학과)
Receptor-mediated gene delivery using chemically modified chitosan
- Kim, T. H.; Jiang, H. L.; Nah, J. W.; Cho, Myung-Haing; Akaike, T.; Cho, C. S.
- Issue Date
- Biomedical Materials (Bristol), Vol.2 No.3, pp.S95-S100
- Chitosan has been investigated as a non-viral vector because it has several advantages such as biocompatibility, biodegradability and low toxicity with high cationic potential. However, the low specificity and low transfection efficiency of chitosan need to be solved prior to clinical application. In this paper, we focused on the galactose or mannose ligand modification of chitosan for enhancement of cell specificity and transfection efficiency via receptor-mediated endocytosis in vitro and in vivo.
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