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Aerosol delivery of eukaryotic translation initiation factor 4E-binding protein 1 effectively suppresses lung tumorigenesis in K-ras(LA1) mice

Cited 10 time in Web of Science Cited 11 time in Scopus
Authors
Chang, S-H; Kim, J-E; Lee, J-H; Minai-Tehrani, A.; Han, K.; Chae, C.; Cho, Y-H; Yun, J-H; Park, K.; Kim, Y-S; Cho, Myung-Haing
Issue Date
2013-06
Citation
Cancer Gene Therapy, Vol.20 No.6, pp.331-335
Keywords
rAAV4E-BP1lung canceraerosol delivery
Abstract
Conventional radiotherapy or chemotherapy for the long-term survival of patients with lung cancer is still difficult for treatment in metastatic and advanced tumors. Therefore, the safe and effective approaches to the treatment of lung cancer are needed. In this study, the effect of delivered eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) on lung cancer progression was evaluated. Recombinant adeno-associated virus (rAAV)-M3/4E-BP1 was delivered into 6-week-old K-ras(LA1) lung cancer model mice through a nose-only inhalation system twice a week for 4 weeks. Long-term repeated delivery of 4E-BP1 effectively reduced tumor progression in the lungs of K-ras(LA1) mice. Reduction of eIF4E by overexpression of 4E-BP1 resulted in suppression of cap-dependent protein expression of basic fibroblast growth factor (bFGF or FGF-2) and vascular endothelial growth factor (VEGF). In addition, delivered 4E-BP1 inhibited the proliferation of lung cancer cells in K-ras(LA1) mice model. Our results suggest that long-term repeated viral delivery of 4E-BP1 may provide a useful tool for designing lung cancer treatment.
ISSN
0929-1903
URI
https://hdl.handle.net/10371/172352
DOI
https://doi.org/10.1038/cgt.2013.24
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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