S-Space College of Veterinary Medicine (수의과대학) Dept. of Veterinary Medicine (수의학과) Journal Papers (저널논문_수의학과)
Inhibitory effects of 7-hydroxy-3-methoxy-cadalene on 4-(methylinitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice
- Kim, Jung Hyon; Lee, Hu Jang; Kim, Gon Sup; Choi, Don Ha; Lee, Sung Suk; Kang, Jong Koo; Chae, Chanhee; Paik, Nam Won; Cho, Myung-Haing
- Issue Date
- Cancer Letters, Vol.213 No.2, pp.139-145
- 7-hydroxy-3-methoxy-cadalene; 4-(methylinitrosamino)-1-(3-pyridyl)-1-butanone; proliferating cell nuclear antigen; tumofigenesis
- The present study was undertaken to estimate the effect of 7-hydroxy-3-methoxycadalene (cadalene) extracted from Zelkova serrata on 4-(methylinitrosamino)-1-(3-pyridyl)-1-!butanone (NNK)-induced lung tumorigenesis in A/J mice. Twenty mice received orally NNK at a dose of 65 mug/ml water for 7 weeks following by free feeding of a commercial diet not containing cadalene for 2 weeks. Control group was maintained without NNK and cadalene administration and/or treatment groups with NNK and cadalene (6.25, 25, 100 mg/kg feed) feeding for 25 weeks. Lung tumors were induced by NNK at incidence ranging from 10 to 45%. Cadalene treatment (100 mg/kg feed) group significantly reduced the incidence of adenomas from 45 to 10% (P < 0.05), and other cadalene treatment group decreased cancer incidences in a concentration dependent manner. The results of our study strongly indicate that cadalene is capable of inhibiting development of NNK-induced lung turnorigenesis in A/J mice. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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