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Chondroitin sulfate extracted from the Styela clava tunic suppresses TNF-α-induced expression of inflammatory factors, VCAM-1 and iNOS by blocking Akt/NF-κB signal in JB6 cells : Chondroitin sulfate extracted from the Styela clava tunic suppresses TNF-alpha-induced expression of inflammatory factors, VCAM-1 and NOS by blocking Akt/NF-kappa B signal in JB6 cells
DC Field | Value | Language |
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dc.contributor.author | Xu, Cheng-Xiong | - |
dc.contributor.author | Jin, Hua | - |
dc.contributor.author | Chung, Youn-Sun | - |
dc.contributor.author | Shin, Ji-Young | - |
dc.contributor.author | Woo, Min-Ah | - |
dc.contributor.author | Lee, Kee-Ho | - |
dc.contributor.author | Palmos, Grace N. | - |
dc.contributor.author | Choi, Byeong-Dae | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.date.accessioned | 2021-01-31T08:41:13Z | - |
dc.date.available | 2021-01-31T08:41:13Z | - |
dc.date.created | 2020-12-16 | - |
dc.date.issued | 2008-06 | - |
dc.identifier.citation | Cancer Letters, Vol.264 No.1, pp.93-100 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.other | 119207 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172354 | - |
dc.description.abstract | Inflammatory mediators are known to play a key role in tumorigenesis, therefore, it is a promising strategy to inhibit the inflammation for cancer prevention and/or treatment. Current study was performed to investigate the effects of chondroitin sulfate (CS) extracted from Styela clava tunic on TNF-alpha-induced inflammation and to elucidate the mechanism of CS on the regulation of inflammatory factors in JB6 cells. Our results showed that CS inhibited TNF-alpha-induced NF-kappa B activation and subsequent vascular cell adhesion molecule 1 and inducible nitric oxide synthase expressions by blocking Akt signals in JB6 cells. Our results suggest that CS may be developed as an effective anti-inflammatory agent in the future. (C) 2008 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Chondroitin sulfate extracted from the Styela clava tunic suppresses TNF-α-induced expression of inflammatory factors, VCAM-1 and iNOS by blocking Akt/NF-κB signal in JB6 cells | - |
dc.title.alternative | Chondroitin sulfate extracted from the Styela clava tunic suppresses TNF-alpha-induced expression of inflammatory factors, VCAM-1 and NOS by blocking Akt/NF-kappa B signal in JB6 cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.1016/j.canlet.2008.01.022 | - |
dc.citation.journaltitle | Cancer Letters | - |
dc.identifier.wosid | 000256011600011 | - |
dc.identifier.scopusid | 2-s2.0-42649098227 | - |
dc.citation.endpage | 100 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 93 | - |
dc.citation.volume | 264 | - |
dc.identifier.sci | 000256011600011 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | MOUSE SKIN | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordAuthor | Styela clava tunic | - |
dc.subject.keywordAuthor | chondroitin sulfate | - |
dc.subject.keywordAuthor | iNOS | - |
dc.subject.keywordAuthor | VCAM-1 | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | akt | - |
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