Browse

Physicochemical Determinants of Multiwalled Carbon Nanotubes on Cellular Toxicity: Influence of a Synthetic Method and Post-treatment

Cited 9 time in Web of Science Cited 10 time in Scopus
Authors
Kim, Ji-Eun; Kang, Seung-Hyon; Moon, Youngmi; Chae, Jin-Joo; Lee, Ah Young; Lee, Jae-Ho; Yu, Kyeong-Nam; Jeong, Dae Hong; Choi, Mansoo; Cho, Myung-Haing
Issue Date
2014-02
Citation
Chemical Research in Toxicology, Vol.27 No.2, pp.290-303
Abstract
Since the discovery of carbon nanotubes (CNTs), scientists have performed extensive studies on nanotubes in the fields of materials science, physics, and electronic engineering. Because multiwalled CNTs (MWCNTs) are not homogeneous materials, and because it is not feasible to test every newly synthesized MWCNT, this study was aimed at investigating the physicochemical properties that primarily determine the cellular toxicity of MWCNTs. This study analyzed the relationship between cell viability and physicochemical characteristics following exposure to eight different MWCNTs. We generated eight different MWCNTs using various synthetic methods and post-treatments. From this analysis, we sought to identify the major physicochemical determinants that could predict the cellular toxicity of MWCNTs, regardless of the synthetic method and post-treatment conditions. Creation of binding sites on the tube walls by breaking C-C bonds played a pivotal role in increasing toxicity and was most clearly demonstrated by a Raman G peak shift and the I-D/I-G ratio. In addition, several factors were found to be strongly related to cellular toxicity: surface charge in the case of MWCNTs created by the chemical vapor deposition method and surface area and EPR intensity in the case of MWCNTs created by the arc discharge based method. The methods developed in this study could be applied to the prediction of the toxicity of newly synthesized MWCNTs.
ISSN
0893-228X
URI
https://hdl.handle.net/10371/172363
DOI
https://doi.org/10.1021/tx400397g
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse