Publications
Detailed Information
Dihydroergotamine Tartrate Induces Lung Cancer Cell Death through Apoptosis and Mitophagy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chang, Seung-Hee | - |
dc.contributor.author | Lee, Ah Young | - |
dc.contributor.author | Yu, Kyeong-Nam | - |
dc.contributor.author | Park, Jongsun | - |
dc.contributor.author | Kim, Kwang Pyo | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.date.accessioned | 2021-01-31T08:41:50Z | - |
dc.date.available | 2021-01-31T08:41:50Z | - |
dc.date.created | 2018-11-06 | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Chemotherapy, Vol.61 No.6, pp.304-312 | - |
dc.identifier.issn | 0009-3157 | - |
dc.identifier.other | 66590 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172365 | - |
dc.description.abstract | Background: Mitochondria have emerged as a major target for anticancer therapy because of their critical role in cancer cell survival. Our preliminary works have suggested that dihydroergotamine tartrate (DHE), an antimigraine agent, may have effects on mitochondria. Methods: We examined the effect of DHE on the survival of several lung cancer cells and confirmed that DHE suppressed diverse lung cancer cell growth effectively. To confirm whether such effects of DHE would be associated with mitochondria, A549 cells were employed for the evaluation of several important parameters, such as membrane potential, reactive oxygen species (ROS) generation, apoptosis, ATP production and autophagy. Results: DHE decreased membrane permeability, increased ROS generation as well as apoptosis, and disturbed ATP production. Eventually, mitophagy was activated for damaged mitochondria. Conclusion: Taken together, our findings demonstrate that DHE induces lung cancer cell death by the induction of apoptosis and mitophagy, thus suggesting that DHE can be developed as an anti-lung cancer therapeutic agent. (C) 2016 S. Karger AG, Basel. | - |
dc.language | 영어 | - |
dc.publisher | S. Karger AG | - |
dc.title | Dihydroergotamine Tartrate Induces Lung Cancer Cell Death through Apoptosis and Mitophagy | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.1159/000445044 | - |
dc.citation.journaltitle | Chemotherapy | - |
dc.identifier.wosid | 000386891600004 | - |
dc.identifier.scopusid | 2-s2.0-84964203407 | - |
dc.citation.endpage | 312 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 304 | - |
dc.citation.volume | 61 | - |
dc.identifier.sci | 000386891600004 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | AEROSOL DELIVERY | - |
dc.subject.keywordPlus | K-RAS(LA1) MICE | - |
dc.subject.keywordPlus | NASAL SPRAY | - |
dc.subject.keywordPlus | MITOCHONDRIA | - |
dc.subject.keywordPlus | MIGRAINE | - |
dc.subject.keywordPlus | TUMORIGENESIS | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | ERGOTAMINE | - |
dc.subject.keywordPlus | AUTOPHAGY | - |
dc.subject.keywordPlus | ERLOTINIB | - |
dc.subject.keywordAuthor | Dihydroergotamine tartrate | - |
dc.subject.keywordAuthor | Reactive oxygen species | - |
dc.subject.keywordAuthor | Adenosine triphosphate depletion | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Mitophagy | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.