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Aerosol gene delivery using viral vectors and cationic carriers for in vivo lung cancer therapy

Cited 18 time in Web of Science Cited 19 time in Scopus
Authors
Hong, Seong-Ho; Park, Sung-Jin; Lee, Somin; Cho, Chong Su; Cho, Myung-Haing
Issue Date
2015-06
Citation
Expert Opinion on Drug Delivery, Vol.12 No.6, pp.977-991
Keywords
aerosol gene deliverycationic polymersgene therapylung cancerviral vectors
Abstract
Introduction: Lung cancer has the highest mortality rate among all cancers in both men and women. Aerosol delivery is a noninvasive method for gene delivery to the lungs, although efficient and biocompatible vectors need to be developed for lung cancer therapy. Areas covered: This review summarizes recent advances in airway gene delivery for lung cancer treatment in animal models using viral vectors or cationic polymers. Viral vectors including lentiviruses and adenoviruses have been used for airway gene delivery because of their high transfection efficiency. Cationic polymers have also been developed for aerosol gene therapy owing to their biocompatibility and ease of modification. Expert opinion: Efficient delivery and specific promoters are needed for lung cancer therapy. Capsid engineering or PEGylation can lower immunogenicity. Moreover, immunotherapy and oncolytic viruses need to be tested with aerosol delivery for lung cancer therapy. Meanwhile, naturally existing cationic materials may allow the development of novel and biocompatible carriers. In combination with various technologies for aerosol delivery, novel and specific carriers could be developed for lung cancer therapy in the future. Finally, standardized protocols for quantifying and manufacturing viral vectors and cationic polymers need to be developed in order to ensure biosafety.
ISSN
1742-5247
URI
https://hdl.handle.net/10371/172381
DOI
https://doi.org/10.1517/17425247.2015.986454
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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