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Physico-chemical characterization-based safety evaluation of nanocalcium
DC Field | Value | Language |
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dc.contributor.author | Jeong, Min Sook | - |
dc.contributor.author | Cho, Hyun Sun | - |
dc.contributor.author | Park, Soo Jin | - |
dc.contributor.author | Song, Kyung Seuk | - |
dc.contributor.author | Ahn, Kyu Sup | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.contributor.author | Kim, Jun Sung | - |
dc.date.accessioned | 2021-01-31T08:42:48Z | - |
dc.date.available | 2021-01-31T08:42:48Z | - |
dc.date.created | 2020-12-10 | - |
dc.date.issued | 2013-12 | - |
dc.identifier.citation | Food and Chemical Toxicology, Vol.62, pp.308-317 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.other | 118959 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172383 | - |
dc.description.abstract | Nano- and microcalcium provided from the KFDA were compared in terms of physico-chemical properties. Calcium samples were tested using EF-TEM and X-ray diffractometry to check for size/morphology and crystal formation, respectively. Two samples of nano- and microcalcium were selected for further evaluation by FE-SEM, DLS (nano-size, 200-500 nm; agglomerate, >5 mu m; micro-size, 1.5-30 mu m), and electron spin resonance. Both samples were heterogeneous in size, existed as single crystal and aggregated form, and did not generate reactive oxygen species. The specific surface area of nano- and microcalcium measured by N2 Brunauere Emmette Teller method was 12.90 +/- 0.27 m(2)/g and 1.12 +/- 0.19 m(2)/g, respectively. Inductively coupled plasma optical emission spectrometry analysis revealed the release of 2-3 times more calcium ion from nano- compared to microcalcium at pH 5 and 7. Genotoxicity and acute single-dose and repeated-dose 14-day oral toxicity testing in SD rats performed to evaluate the safety of nanocalcium did not reveal toxicity. However, long-term monitoring will be required for an unequivocal conclusion. A nanocalcium dose of 1 g/kg is recommended as the maximum dose for repeated dose 13-week oral toxicity. Further studies could provide details of toxicity of nanocalcium on the repeated dose 13-week oral toxicity test. (C) 2013 Elsevier Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Physico-chemical characterization-based safety evaluation of nanocalcium | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.1016/j.fct.2013.08.024 | - |
dc.citation.journaltitle | Food and Chemical Toxicology | - |
dc.identifier.wosid | 000329960400041 | - |
dc.identifier.scopusid | 2-s2.0-84884391683 | - |
dc.citation.endpage | 317 | - |
dc.citation.startpage | 308 | - |
dc.citation.volume | 62 | - |
dc.identifier.sci | 000329960400041 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | OVARIECTOMIZED RATS | - |
dc.subject.keywordPlus | PARTICLE-SIZE | - |
dc.subject.keywordPlus | NANOTOXICOLOGY | - |
dc.subject.keywordPlus | NANOTECHNOLOGY | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordAuthor | Nanocalcium | - |
dc.subject.keywordAuthor | Genotoxicity | - |
dc.subject.keywordAuthor | Physico-chemical characteristics | - |
dc.subject.keywordAuthor | Specific surface area | - |
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