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Roles of protein kinase B/Akt in lung cancer

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Authors
Xu, Cheng-Xiong; Jin, Hua Jin; Shin, Ji-Young; Kim, Ji-Eun; Hong, Choong-Man; Cho, Myung-Haing
Issue Date
2010-01
Citation
Frontiers in Bioscience - Elite, Vol.2 E No.4, pp.1472-1484
Keywords
AktLung tumorigenesisProtein kinase BTherapeutic resistance
Abstract
Lung cancer is the leading cause of cancerrelated death worldwide and has frequently been associated with over-activated protein kinase B (PKB)/Akt. Akt is a serine/threonine protein kinase that plays an important role in cell growth, proliferation, and survival. Many lines of evidence point to the contribution of deregulated Akt in development or progression of lung cancer. In addition, recent studies have demonstrated that cancer cells defend themselves from therapeutic treatment through activation of pro-survival signals, including the Akt pathway. In this review, we described the way in which the Akt pathway is activated in development and progression of lung cancer, and the way in which deregulated Akt plays a significant role in lung tumorigenesis and resistance to chemo- or radiotherapy. In this review, we also discussed the potential of the Akt pathway as a target of lung cancer therapy.
ISSN
1945-0494
URI
https://hdl.handle.net/10371/172388
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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