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Safety evaluation of cricket(Gryllus bimaculatus) extract in Sprague-Dawley rats

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Authors
Lee, Somin; Ahn, Kyu Sup; Ryu, Hyeon Yeol; Kim, Hye Jin; Lee, Jin Kyu; Cho, Myung-Haing; Ahn, Mi Young; Song, Kyung Seuk
Issue Date
2016-03
Citation
International Journal of Industrial Entomology, Vol.32 No.1, pp.12-25
Keywords
cricketcricket ethanol extractGryllus bimaculatusNOAEL
Abstract
Recently, research investment in the improvement of food safety as a food source and specializing of nutritional source of edible insects is being actively conducted. Cricket especially has been attracting considerable interest in entomophagy; however, research on the safety assessment of cricket is limited. This study investigated the effects of cricket ethanol extract when orally administrated in Sprague-Dawley rats. Here, we performed a 4 wk repeated oral dose toxicity test in Sprague-Dawley rats following the Organization for Economic Cooperation and Development test guidelines 407 under Good Laboratory Practice regulation. Rats were randomly allocated 4 groups: vehicle control, 250, 500, 1,000 mg/kg test groups and administrated based on body weight for 28 d. The animals were observed for mortalities and clinical signs, body weight changes, food and water consumption. At the end of treatment period, blood and urine were collected and analyzed. Subsequently, the animals were sacrificed and subjected to gross pathological examination and organ weight measurement. The organs were preserved for histopathological examination. The results showed that there were no systemic toxicological effects related with the cricket ethanol extract in the 4 wk oral repeated dose toxicity study. It is considered that NOAEL of cricket ethanol extract is greater than 1,000 mg/kg/d and there was no target organ detected.
ISSN
1598-3579
URI
https://hdl.handle.net/10371/172392
DOI
https://doi.org/10.7852/ijie.2016.32.1.12
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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