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Activation of protein kinase C by 1-β-D-arabinofuranosylcytosine conjugates of phospholipid : Activation of protein kinase C by 1-beta-D-arabinofuranosylcytosine conjugates of phospholipid
DC Field | Value | Language |
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dc.contributor.author | Lee, KH | - |
dc.contributor.author | Jung, YJ | - |
dc.contributor.author | Hong, CI | - |
dc.contributor.author | Cho, MH | - |
dc.contributor.author | Bai, DH | - |
dc.contributor.author | Kim, SH | - |
dc.contributor.author | Choi, KY | - |
dc.contributor.author | Yu, JH | - |
dc.contributor.author | Kim, CM | - |
dc.date.accessioned | 2021-01-31T08:43:39Z | - |
dc.date.available | 2021-01-31T08:43:39Z | - |
dc.date.created | 2018-04-11 | - |
dc.date.issued | 2004-01 | - |
dc.identifier.citation | International Journal of Oncology, Vol.24 No.1, pp.193-199 | - |
dc.identifier.issn | 1019-6439 | - |
dc.identifier.other | 32028 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172397 | - |
dc.description.abstract | 1-beta-D-arabinofuranosylcytosine (ara-C) conjugates of phospholipid were shown to be highly antineoplastic against various tumor cells. In this study, we report that these conjugates are potent activators of protein kinase C (PKC, EC) in vitro. Although required Ca2+, PKC activation by the conjugates occurred even in the absence of phospholipid and diacylglycerol. Among the conjugates, 1-beta-D-arabinofuranosylcytosine 5'-diphosphate-rac-1-O-octadecyl-2-O-palmitoylglycerol [(ara-CDP-DL-PBA); ara-C conjugate of ether phospholipid], was employed to investigate its mode of activation, since ether phospholipid has been reported to be a regulator of the PKC. When PKC was activated by ara-CDP-DL-PBA, diacylglycerol enhanced its activity with 3-fold reduction of an apparent Ka value for ara-CDP-DL-PBA and no change in the Vmax. During the PKC activation by phosphatidylserine, ara-CDP-DL-PBA exhibited a synergistic effect on the activation. Studies on the relationship between the structures of ara-CDP-DL-PBA and their effects on PKC activity showed that phosphate group of ether lipid was important for its activation of PKC, and that conjugation of ara-C and ether lipid further enhanced the enzyme activity. These results suggest that the ara-C conjugate of phospholipid activates PKC in a co-operative manner with diacylglycerol and/ or phosphatidylserine, however, the exact mechanism of the antineoplastic effect of ara-CDP-DL-PBA through PKC activation still remains speculative. | - |
dc.language | 영어 | - |
dc.publisher | Demetrios A. Spandidos Ed. & Pub. | - |
dc.title | Activation of protein kinase C by 1-β-D-arabinofuranosylcytosine conjugates of phospholipid | - |
dc.title.alternative | Activation of protein kinase C by 1-beta-D-arabinofuranosylcytosine conjugates of phospholipid | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.3892/ijo.24.1.193 | - |
dc.citation.journaltitle | International Journal of Oncology | - |
dc.identifier.wosid | 000187359500023 | - |
dc.identifier.scopusid | 2-s2.0-3843116743 | - |
dc.citation.endpage | 199 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 193 | - |
dc.citation.volume | 24 | - |
dc.identifier.sci | 000187359500023 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, MH | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ETHER LIPID ANALOGS | - |
dc.subject.keywordPlus | IMPROVED WATER SOLUBILITY | - |
dc.subject.keywordPlus | HUMAN LEUKEMIC-CELLS | - |
dc.subject.keywordPlus | ANTI-TUMOR ACTIVITY | - |
dc.subject.keywordPlus | ANTITUMOR-ACTIVITY | - |
dc.subject.keywordPlus | LINKED DIGLYCERIDES | - |
dc.subject.keywordPlus | ALKYL-LYSOPHOSPHOLIPIDS | - |
dc.subject.keywordPlus | SELECTIVE DESTRUCTION | - |
dc.subject.keywordPlus | THIOETHER LIPIDS | - |
dc.subject.keywordPlus | MIXED MICELLES | - |
dc.subject.keywordAuthor | protein kinase C | - |
dc.subject.keywordAuthor | ara-C conjugates | - |
dc.subject.keywordAuthor | ether lipid | - |
dc.subject.keywordAuthor | phosphorylation | - |
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