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Decreased Level of PDCD4 (Programmed Cell Death 4) Protein Activated Cell Proliferation in the Lung of A/J Mouse

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dc.contributor.authorHwang, Soon-Kyung-
dc.contributor.authorMinai-Tehrani, Arash-
dc.contributor.authorLim, Hwang-Tae-
dc.contributor.authorShin, Ji-Young-
dc.contributor.authorAn, Gil-Hwan-
dc.contributor.authorLee, Kee-Ho-
dc.contributor.authorPark, Kee-Rang-
dc.contributor.authorKim, Yeon-Soo-
dc.contributor.authorBeck, George R., Jr.-
dc.contributor.authorYang, Hsin-Sheng-
dc.contributor.authorCho, Myung-Haing-
dc.date.accessioned2021-01-31T08:44:16Z-
dc.date.available2021-01-31T08:44:16Z-
dc.date.issued2010-10-
dc.identifier.citationJournal of Aerosol Medicine and Pulmonary Drug Delivery, Vol.23 No.5, pp.285-293-
dc.identifier.issn1941-2711-
dc.identifier.other14355-
dc.identifier.urihttps://hdl.handle.net/10371/172409-
dc.description.abstractBackground: Programmed cell death 4 (PDCD4), a protein that binds to eukaryotic initiation factor 4A (eIF4A), inhibits the initiation of translation. Although a number of tumor suppressors target transcription, Pdcd4 is the first suppressor targeting protein translation, and has also been suggested to function as a tumor suppressor gene in human cancer. The majority of tumor suppressors are mutationally inactivated, but the expression of Pdcd4 is downregulated with progression in a number of human cancer sites, including the lung. Methods: An aerosol of lentivirus-shRNA Pdcd4 was delivered into A/J mice, through a nose-only inhalation system twice a week for 1 month. Results and Conclusions: Downregulated Pdcd4 resulted in increase levels of antiapoptotic and uPA-regulated proteins. We also found that downregulated Pdcd4 induced the mTOR/p70S6K pathway and cell-cycle proteins. Our results suggest that Pdcd4 may perform a critical function in the regulation of lung cancer cell proliferation.-
dc.subjectaerosol gene delivery-
dc.subjectshRNA Pdcd4-
dc.subjectlung cell proliferation-
dc.titleDecreased Level of PDCD4 (Programmed Cell Death 4) Protein Activated Cell Proliferation in the Lung of A/J Mouse-
dc.typeArticle-
dc.contributor.AlternativeAuthor조명행-
dc.identifier.doi10.1089/jamp.2009.0778-
dc.citation.journaltitleJournal of Aerosol Medicine and Pulmonary Drug Delivery-
dc.identifier.scopusid2-s2.0-77958149807-
dc.citation.endpage293-
dc.citation.number5-
dc.citation.startpage285-
dc.citation.volume23-
dc.identifier.rimsid14355-
dc.identifier.sci000282812300003-
dc.contributor.affiliatedAuthorCho, Myung-Haing-
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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