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Decreased Level of PDCD4 (Programmed Cell Death 4) Protein Activated Cell Proliferation in the Lung of A/J Mouse
DC Field | Value | Language |
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dc.contributor.author | Hwang, Soon-Kyung | - |
dc.contributor.author | Minai-Tehrani, Arash | - |
dc.contributor.author | Lim, Hwang-Tae | - |
dc.contributor.author | Shin, Ji-Young | - |
dc.contributor.author | An, Gil-Hwan | - |
dc.contributor.author | Lee, Kee-Ho | - |
dc.contributor.author | Park, Kee-Rang | - |
dc.contributor.author | Kim, Yeon-Soo | - |
dc.contributor.author | Beck, George R., Jr. | - |
dc.contributor.author | Yang, Hsin-Sheng | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.date.accessioned | 2021-01-31T08:44:16Z | - |
dc.date.available | 2021-01-31T08:44:16Z | - |
dc.date.created | 2018-01-10 | - |
dc.date.issued | 2010-10 | - |
dc.identifier.citation | Journal of Aerosol Medicine and Pulmonary Drug Delivery, Vol.23 No.5, pp.285-293 | - |
dc.identifier.issn | 1941-2711 | - |
dc.identifier.other | 14355 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172409 | - |
dc.description.abstract | Background: Programmed cell death 4 (PDCD4), a protein that binds to eukaryotic initiation factor 4A (eIF4A), inhibits the initiation of translation. Although a number of tumor suppressors target transcription, Pdcd4 is the first suppressor targeting protein translation, and has also been suggested to function as a tumor suppressor gene in human cancer. The majority of tumor suppressors are mutationally inactivated, but the expression of Pdcd4 is downregulated with progression in a number of human cancer sites, including the lung. Methods: An aerosol of lentivirus-shRNA Pdcd4 was delivered into A/J mice, through a nose-only inhalation system twice a week for 1 month. Results and Conclusions: Downregulated Pdcd4 resulted in increase levels of antiapoptotic and uPA-regulated proteins. We also found that downregulated Pdcd4 induced the mTOR/p70S6K pathway and cell-cycle proteins. Our results suggest that Pdcd4 may perform a critical function in the regulation of lung cancer cell proliferation. | - |
dc.language | 영어 | - |
dc.publisher | Mary Ann Liebert Inc. | - |
dc.title | Decreased Level of PDCD4 (Programmed Cell Death 4) Protein Activated Cell Proliferation in the Lung of A/J Mouse | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.1089/jamp.2009.0778 | - |
dc.citation.journaltitle | Journal of Aerosol Medicine and Pulmonary Drug Delivery | - |
dc.identifier.wosid | 000282812300003 | - |
dc.identifier.scopusid | 2-s2.0-77958149807 | - |
dc.citation.endpage | 293 | - |
dc.citation.number | 5 | - |
dc.citation.startpage | 285 | - |
dc.citation.volume | 23 | - |
dc.identifier.sci | 000282812300003 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | RAS NULL MICE | - |
dc.subject.keywordPlus | SUPPRESSOR PDCD4 | - |
dc.subject.keywordPlus | PROSTATE-CANCER | - |
dc.subject.keywordPlus | UROKINASE | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | TRANSLATION | - |
dc.subject.keywordPlus | AEROSOL | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordAuthor | aerosol gene delivery | - |
dc.subject.keywordAuthor | shRNA Pdcd4 | - |
dc.subject.keywordAuthor | lung cell proliferation | - |
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