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Chondroitin Sulfate Extracted from Ascidian Tunic Inhibits Phorbol Ester-Induced Expression of Inflammatory Factors VCAM-1 and COX-2 by Blocking NF-kappa B Activation in Mouse Skin

Cited 12 time in Web of Science Cited 15 time in Scopus
Authors
Xu, Cheng-Xiong; Jin, Hua; Chung, Youn-Sun; Shin, Ji-Young; Lee, Kee-Ho; Beck, George R., Jr.; Palmos, Grace N.; Choi, Byeong-Dae; Cho, Myung-Haing
Issue Date
2008-10
Citation
Journal of Agricultural and Food Chemistry, Vol.56 No.20, pp.9667-9675
Keywords
Ascidian tunicchondroitin sulfateVCAM-1COX-2NF-kappa BAkt
Abstract
Inflammatory factors are known to play a key role in promoting tumorigenesis; therefore, it is a promising strategy to inhibit the inflammation for cancer prevention. The current study was performed to investigate the potential effects of chondroitin sulfate (CS) extracted from ascidian tunic on the expression of inflammatory factors induced by treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) and to elucidate the underlying molecular mechanism of CS action in mouse skin inflammation. TPA was topically applied to the shaven backs of ICR mice with or without CS (1 or 2 mg) for 4 h. The results demonstrated that CS suppressed TPA-induced edema and reduced the expression of cyclooxygenase-2, vascular cell adhesion molecule-1, and Akt signaling in mouse skin. These studies suggest that CS from ascidian tunic may be developed as an effective natural anti-inflammatory agent.
ISSN
0021-8561
URI
https://hdl.handle.net/10371/172412
DOI
https://doi.org/10.1021/jf801578x
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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