Browse

Body distribution of inhaled fluorescent magnetic nanoparticles in the mice

Cited 119 time in Web of Science Cited 144 time in Scopus
Issue Date
2008-01
Citation
Journal of Occupational Health, Vol.50 No.1, pp.1-6
Keywords
fluorescent magnetic nanoparticlesinhalationmice
Abstract
Reducing the particle size of materials is an efficient and reliable tool for improving the bioavailability of a gene or drug delivery system. In fact, nanotechnology helps in overcoming the limitations of size and can change the outlook of the world regarding science. However, a potential harmful effect of nanomaterial on workers manufacturing nanoparticles is expected in the workplace and the lack of information regarding body distribution of inhaled nanoparticles may pose serious problem. In this study, we addressed this question by studying the body distribution of inhaled nanoparticles in mice using approximately 50-nm fluorescent magnetic nanoparticles (FMNPs) as a model of nanoparticles through nose-only exposure chamber system developed by our group. Scanning mobility particle sizer (SMPS) analysis revealed that the mice were exposed to FMNPs with a total particle number of 4.89 x 10(5) +/- 2.37 x 10(4)/cm(3) (low concentration) and 9.34 x 10(5) +/- 5.11 X 10(4)/cm(3) (high concentration) for 4 wk (4 h/d, 5 d/wk). The body distribution of FMNPs was examined by magnetic resonance imaging (MRI) and Confocal Laser Scanning Microscope (CLSM) analysis. FMNPs were distributed in various organs, including the liver, testis, spleen, lung and brain. T2-weighted spin-echo MR images showed that FMNPs could penetrate the blood-brain-barrier (BBB). Application of nanotechnologies should not produce adverse effects on human health and the environment. To predict and prevent the potential toxicity of nanomaterials, therefore, extensive studies should be performed under different routes of exposure with different sizes and shapes of nanomaterials.
ISSN
1341-9145
URI
https://hdl.handle.net/10371/172443
DOI
https://doi.org/10.1539/joh.50.1
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse