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Methylmercury induces caspase-dependent apoptosis and autophagy in human neural stem cells

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Authors
Chang, Seung-Hee; Lee, Hong Jun; Kang, Bitna; Yu, Kyeong-Nam; Minai-Tehrani, Arash; Lee, Somin; Kim, Seung U.; Cho, Myung-Haing
Issue Date
2013-12
Citation
Journal of Toxicological Sciences, Vol.38 No.6, pp.823-831
Keywords
Methylmercury (MeHg)Human neural stem cell (NSC)ApoptosisAutophagy
Abstract
Methylmercury (MeHg) is a well-known human neurotoxic agent whose exposure sources are mainly environmental and aquatic-derived food. MeHg is reported to induce central nervous system disability. However, the exact mechanism of MeHg-induced neurotoxicity is still unknown. In this study, to investigate which cell death signaling pathway is related with MeHg-induced cytotoxicity, the effects of MeHg on apoptosis and autophagy were evaluated in HB1.F3 human neural stem cells (NSCs). Human NSCs were treated with 1 mu M of MeHg for 48 hr and the effect of MeHg on cell signaling pathway was elucidated. MeHg inhibited Akt1/mTOR signaling that led to induction of caspase-dependent apoptosis and autophagy in the NSCs. Furthermore, retinoic acid (RA)-induced neuronal differentiation was inhibited by MeHg. Taken together, these results suggest that MeHg inhibits the differentiation of human NSCs by induction of caspase-dependent apoptosis and autophagy.
ISSN
0388-1350
URI
https://hdl.handle.net/10371/172447
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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