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Toxicity and Clearance of Intratracheally Administered Multiwalled Carbon Nanotubes from Murine Lung

Cited 38 time in Web of Science Cited 41 time in Scopus
Authors
Kim, Ji-Eun; Lim, Hwang-Tae; Minai-Tehrani, Arash; Kwon, Jung-Taek; Shin, Ji-Young; Woo, Chang-Gyu; Choi, Mansoo; Baek, Jongho; Jeong, Dae Hong; Ha, Yoon-Cheol; Chae, Chan-Hee; Song, Kyung-Suk; Ahn, Kang-Ho; Lee, Ji-Hyun; Sung, Ha-Jung; Yu, Il-Je; Beck, George R., Jr.; Cho, Myung-Haing
Issue Date
2010-10
Citation
Journal of Toxicology and Environmental Health - Part A, Vol.73 No.21-22, pp.1530-1543
Abstract
Carbon nanotubes (CNT) are known to have widespread industrial applications; however, several reports indicated that these compounds may be associated with adverse effects in humans. In this study, multiwalled carbon nanotubes were administered to murine lungs intratracheally to determine whether acute and chronic pulmonary toxicity occurred. In particular, pristine multiwalled carbon nanotubes (PMWCNT) and acid-treated multiwalled carbon nanotubes (TMWCNT) were used in this study. In broncheoalveolar lavage fluid (BALF) cell analysis, PMWCNT induced more severe acute inflammatory cell recruitment than TMWCNT. Histopathologically, both PMWCNT and TMWCNT induced multifocal inflammatory granulomas in a dose-dependent manner. The observed granulomas were reversible, with TMWCNT-induced granulomas diminishing faster than PMWCNT-induced granulomas. Although the area of granuloma reduced with time, hyperplasia and dysplastic characteristics such as mitotic figures, anisokaryosis, and anisocytosis were still observed. These findings demonstrate that MWCNT induces granulomatous inflammation, and the duration and pattern of inflammation seem to vary depending upon the types of MWCNT to which mice are exposed. Therefore, toxicity studies on various types of CNT are needed as the responsiveness to these compounds differs.
ISSN
1528-7394
URI
https://hdl.handle.net/10371/172452
DOI
https://doi.org/10.1080/15287394.2010.511578
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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