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Differential toxic responses between pristine and functionalized multiwall nanotubes involve induction of autophagy accumulation in murine lung

Cited 23 time in Web of Science Cited 24 time in Scopus
Authors
Yu, Kyeong-Nam; Kim, Ji Eun; Seo, Hwi Won; Chae, Chanhee; Cho, Myung-Haing
Issue Date
2013-12
Citation
Journal of Toxicology and Environmental Health - Part A, Vol.76 No.23, pp.1282-1292
Abstract
Carbon nanotubes (CNT) are becoming commonly used in industrial applications. However, the toxicity associated with this material remains to be established. The aim of this study was to investigate the potential toxic mechanisms associated with multiwall carbon nanotubes (MWCNT) in normal mouse lung. A total of 100 g of two types of MWCNT, namely, pristine MWCNT (PMWCNT) and acid-treated-MWCNT (TMWCNT), was administered to male C57BL/6 mice via intratracheal (IT) instillation for a period of 6 mo. Our results indicated that PMWCNT induced pulmonary autophagy accumulation and resulted in more potent tumorigenic effects compared to TMWCNT. Accordingly, MWCNT may exert differential toxicity attributed to various physicochemical properties. Data emphasize the need for careful regulation of production and use of CNT.
ISSN
1528-7394
URI
https://hdl.handle.net/10371/172453
DOI
https://doi.org/10.1080/15287394.2013.850137
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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