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Low dietary inorganic phosphate affects the lung growth of developing mice

Cited 7 time in Web of Science Cited 8 time in Scopus
Authors
Xu, Cheng-Xiong; Jin, Hua; Chung, Youn-Sun; Shin, Ji-Young; Hwang, Soon-Kyung; Kwon, Jung-Taek; Park, Sung-Jin; Lee, Eun-Sun; Minai-Tehrani, Arash; Chang, Seung-Hee; Woo, Min-Ah; Noh, Mi-Suk; An, Gil-Hwan; Lee, Kee-Ho; Cho, Myung-Haing
Issue Date
2009-06
Citation
Journal of Veterinary Science, Vol.10 No.2, pp.105-113
Keywords
Aktfibroblast growth factorinorganic phosphatelung
Abstract
Inorganic phosphate (Pi) plays a critical role in diverse cellular functions, and regulating the Pi balance is accomplished by sodium-dependent Pi co-transporter (NPT). Pulmonary NPT has recently been identified in mammalian lungs. However, to date, many of the studies that have involved Pi have mainly focused on its effect on bone and kidney. Therefore, current study was performed to discover the potential effects of low Pi on the lung of developing transgenic mice expressing the renilla/firefly luciferase dual reporter gene. Two-weeks old male mice divided into 2 groups and these groups were fed either a low PI diet or a normal control diet (normal: 0.5% Pi, low: 0.1% Pi) for 4 weeks. After 4 weeks of the diet, all the mice were sacrificed. Their lungs were harvested and analyzed by performing luciferase assay, Western blotting, kinase assay and immunohistochemistry. Our results demonstrate that low Pi affects the lungs of developing mice by disturbing protein translation, the cell cycle and the expression of fibroblast growth factor-2. These results suggest that optimally regulating Pi consumption may be important to maintain health.
ISSN
1229-845X
URI
https://hdl.handle.net/10371/172458
DOI
https://doi.org/10.4142/jvs.2009.10.2.105
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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