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[6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin : [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin
DC Field | Value | Language |
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dc.contributor.author | Kim, Sue Ok | - |
dc.contributor.author | Kundu, Joydeb Kumar | - |
dc.contributor.author | Shin, Young Kee | - |
dc.contributor.author | Park, Jin Hong | - |
dc.contributor.author | Cho, Myung Haing | - |
dc.contributor.author | Kim, Tae-Yoon | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T08:49:07Z | - |
dc.date.available | 2021-01-31T08:49:07Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2005-04 | - |
dc.identifier.citation | Oncogene, Vol.24 No.15, pp.2558-2567 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.other | 3995 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172491 | - |
dc.description.abstract | [6]-Gingerol, a pungent ingredient of ginger (Zingiber officinale Roscoe, Zingiberaceae), has a wide array of pharmacologic effects. The present study was aimed at unraveling the molecular mechanisms underlying previously reported antitumor promoting effects of [6]- gingerol in mouse skin in vivo. One of the well-recognized molecular targets for chemoprevention is cyclooxygenase-2 (COX-2) that is abnormally upregulated in many premalignant and malignant tissues and cells. In our present study, topical application of [6]- gingerol inhibited COX-2 expression in mouse skin stimulated with a prototype tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Since the transcription factor nuclear factor-kappaB (NF-KB) is known to regulate COX-2 induction, we attempted to determine the effect of [6]- gingerol on TPA-induced activation of NF-KB. Pretreatment with [6]-gingerol resulted in a decrease in both TPA-induced DNA binding and transcriptional activities of NF-KB through suppression of IKB alpha degradation and p65 nuclear translocation. Phosphorylation of both IKB alpha and p65 was substantially blocked by [6]-gingerol. In addition, [6]-gingerol inhibited TPA-stimulated interaction of phospho-p65-(Ser-536) with cAMP response element binding protein-binding protein, a transcriptional coactivator of NF-KB. Moreover, [6]-gingerol prevented TPA-induced phosphorylation and catalytic activity of p38 mitogen-activated protein ( MAP) kinase that regulates COX-2 expression in mouse skin. The p38 MAP kinase inhibitor SB203580 attenuated NF-KB activation and subsequent COX-2 induction in TPA-treated mouse skin. Taken together, our data suggest that [6]-gingerol inhibits TPA-induced COX-2 expression in mouse skin in vivo by blocking the p38 MAP kinase-NF-KB signaling pathway. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin | - |
dc.title.alternative | [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1038/sj.onc.1208446 | - |
dc.citation.journaltitle | Oncogene | - |
dc.identifier.wosid | 000228180600013 | - |
dc.identifier.scopusid | 2-s2.0-17844362777 | - |
dc.citation.endpage | 2567 | - |
dc.citation.number | 15 | - |
dc.citation.startpage | 2558 | - |
dc.citation.volume | 24 | - |
dc.identifier.sci | 000228180600013 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Shin, Young Kee | - |
dc.contributor.affiliatedAuthor | Cho, Myung Haing | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION PATHWAYS | - |
dc.subject.keywordPlus | NITRIC-OXIDE-SYNTHASE | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 EXPRESSION | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL ACTIVITY | - |
dc.subject.keywordPlus | MOLECULAR-MECHANISMS | - |
dc.subject.keywordPlus | CELL-TRANSFORMATION | - |
dc.subject.keywordPlus | BINDING PROTEIN | - |
dc.subject.keywordPlus | P65 SUBUNIT | - |
dc.subject.keywordAuthor | chemoprevention | - |
dc.subject.keywordAuthor | cyclooxygenase-2 | - |
dc.subject.keywordAuthor | [6]-gingerol | - |
dc.subject.keywordAuthor | p38 MAPK | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | mouse skin | - |
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