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Inhibitors of 5 alpha-reductase type I in LNCaP cells from the roots of Angelica koreana
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, Eun-Kyoung | - |
dc.contributor.author | Kim, Kyeong Ho | - |
dc.contributor.author | Kim, Min Ki | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.contributor.author | Choi, Eunwook | - |
dc.contributor.author | Kim, Kinam | - |
dc.contributor.author | Mar, Woong Chon | - |
dc.date.accessioned | 2021-01-31T08:49:28Z | - |
dc.date.available | 2021-01-31T08:49:28Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2002-02 | - |
dc.identifier.citation | Planta Medica, Vol.68 No.2, pp.162-163 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.other | 4729 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172498 | - |
dc.description.abstract | A prenylated coumarin, osthenol (1) and a sesquiterpene, bisabolangelone (2) have been isolated as active principles with 5alpha-reductase type I inhibitory effects in LNCaP cells from the roots of Angelica koreana Max. by bioassay-guided chromatographic fractionation. Osthenol exhibited a highly potent inhibitory activity on 5alpha-reductase type I in LNCaP cells with an IC50 value of 0.1 mug/ml, which is about 200 times more potent than the positive control, finasteride (IC50 = 19.8 mug/ml). Bisabolangelone also inhibited the activity of 5alpha-reductase type I in LNCaP cells (IC50 = 11.6 mug/ml), indicating that these compounds are possible candidates for the development of new drugs to treat human endocrine disorders associated with overproduction of DHT by 5 a-reductase type I. In addition, four compounds isooxypeucedanin, oxypeucedanin hydrate, oxypeucedanin and isoimperatorin were also isolated and found to be inactive in the 5alpha-reductase assay systems used in the present study. | - |
dc.language | 영어 | - |
dc.publisher | Georg Thieme Verlag | - |
dc.title | Inhibitors of 5 alpha-reductase type I in LNCaP cells from the roots of Angelica koreana | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.1055/s-2002-20258 | - |
dc.citation.journaltitle | Planta Medica | - |
dc.identifier.wosid | 000174160000015 | - |
dc.identifier.scopusid | 2-s2.0-0036178199 | - |
dc.citation.endpage | 163 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 162 | - |
dc.citation.volume | 68 | - |
dc.identifier.sci | 000174160000015 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.contributor.affiliatedAuthor | Mar, Woong Chon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | COUMARINS | - |
dc.subject.keywordPlus | VITRO | - |
dc.subject.keywordPlus | NMR | - |
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