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Suppression of Lung Tumorigenesis by Leucine Zipper/EF Hand-Containing Transmembrane-1

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dc.contributor.authorHwang, Soon-Kyung-
dc.contributor.authorPiao, Longzhen-
dc.contributor.authorLim, Hwang-Tae-
dc.contributor.authorMinai-Tehrani, Arash-
dc.contributor.authorYu, Kyeong-Nam-
dc.contributor.authorHa, Youn-Cheol-
dc.contributor.authorChae, Chan-Hee-
dc.contributor.authorLee, Kee-Ho-
dc.contributor.authorBeck, George R., Jr.-
dc.contributor.authorPark, Jongsun-
dc.contributor.authorCho, Myung-Haing-
dc.date.accessioned2021-01-31T08:49:34Z-
dc.date.available2021-01-31T08:49:34Z-
dc.date.issued2010-09-
dc.identifier.citationPLoS ONE, Vol.5 No.9, p. e12535-
dc.identifier.issn1932-6203-
dc.identifier.other119180-
dc.identifier.urihttps://hdl.handle.net/10371/172499-
dc.description.abstractBackground: Leucine zipper/EF hand-containing transmembrane-1 (LETM1) encodes for the human homologue of yeast Mdm38p, which is a mitochondria-shaping protein of unclear function. However, a previous study demonstrated that LETM1 served as an anchor protein for complex formation between mitochondria and ribosome, and regulated mitochondrial biogenesis. Methodology/Principal Findings: Therefore, we examine the possibility that LETM1 may function to regulate mitochondria and lung tumor growth. In this study, we addressed this question by studying in the effect of adenovirus-mediated LETM1 in the lung cancer cell and lung cancer model mice. To investigate the effects of adenovirus-LETM1 in vitro, we infected with adenovirus-LETM1 in A549 cells. Additionally, in vivo effects of LETM1 were evaluated on K-ras LA1 mice, human non-small cell lung cancer model mice, by delivering the LETM1 via aerosol through nose-only inhalation system. The effects of LETM1 on lung cancer growth and AMPK related signals were evaluated. Adenovirus-mediated overexpression of LETM1 could induce destruction of mitochondria of lung cancer cells through depleting ATP and AMPK activation. Furthermore, adenoviral-LETM1 also altered Akt signaling and inhibited the cell cycle while facilitating apoptosis. Theses results demonstrated that adenovirus-LETM1 suppressed lung cancer cell growth in vitro and in vivo. Conclusions/Significance: Adenovirus-mediated LETM1 may provide a useful target for designing lung tumor prevention and treatment.-
dc.titleSuppression of Lung Tumorigenesis by Leucine Zipper/EF Hand-Containing Transmembrane-1-
dc.typeArticle-
dc.contributor.AlternativeAuthor조명행-
dc.identifier.doi10.1371/journal.pone.0012535-
dc.citation.journaltitlePLoS ONE-
dc.identifier.scopusid2-s2.0-77958601292-
dc.citation.number9-
dc.citation.startpagee12535-
dc.citation.volume5-
dc.identifier.rimsid119180-
dc.identifier.sci000281480900018-
dc.contributor.affiliatedAuthorCho, Myung-Haing-
Appears in Collections:
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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