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Suppression of Lung Tumorigenesis by Leucine Zipper/EF Hand-Containing Transmembrane-1
DC Field | Value | Language |
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dc.contributor.author | Hwang, Soon-Kyung | - |
dc.contributor.author | Piao, Longzhen | - |
dc.contributor.author | Lim, Hwang-Tae | - |
dc.contributor.author | Minai-Tehrani, Arash | - |
dc.contributor.author | Yu, Kyeong-Nam | - |
dc.contributor.author | Ha, Youn-Cheol | - |
dc.contributor.author | Chae, Chan-Hee | - |
dc.contributor.author | Lee, Kee-Ho | - |
dc.contributor.author | Beck, George R., Jr. | - |
dc.contributor.author | Park, Jongsun | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.date.accessioned | 2021-01-31T08:49:34Z | - |
dc.date.available | 2021-01-31T08:49:34Z | - |
dc.date.created | 2020-12-15 | - |
dc.date.issued | 2010-09 | - |
dc.identifier.citation | PLoS ONE, Vol.5 No.9, p. e12535 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.other | 119180 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172499 | - |
dc.description.abstract | Background: Leucine zipper/EF hand-containing transmembrane-1 (LETM1) encodes for the human homologue of yeast Mdm38p, which is a mitochondria-shaping protein of unclear function. However, a previous study demonstrated that LETM1 served as an anchor protein for complex formation between mitochondria and ribosome, and regulated mitochondrial biogenesis. Methodology/Principal Findings: Therefore, we examine the possibility that LETM1 may function to regulate mitochondria and lung tumor growth. In this study, we addressed this question by studying in the effect of adenovirus-mediated LETM1 in the lung cancer cell and lung cancer model mice. To investigate the effects of adenovirus-LETM1 in vitro, we infected with adenovirus-LETM1 in A549 cells. Additionally, in vivo effects of LETM1 were evaluated on K-ras LA1 mice, human non-small cell lung cancer model mice, by delivering the LETM1 via aerosol through nose-only inhalation system. The effects of LETM1 on lung cancer growth and AMPK related signals were evaluated. Adenovirus-mediated overexpression of LETM1 could induce destruction of mitochondria of lung cancer cells through depleting ATP and AMPK activation. Furthermore, adenoviral-LETM1 also altered Akt signaling and inhibited the cell cycle while facilitating apoptosis. Theses results demonstrated that adenovirus-LETM1 suppressed lung cancer cell growth in vitro and in vivo. Conclusions/Significance: Adenovirus-mediated LETM1 may provide a useful target for designing lung tumor prevention and treatment. | - |
dc.language | 영어 | - |
dc.publisher | Public Library of Science | - |
dc.title | Suppression of Lung Tumorigenesis by Leucine Zipper/EF Hand-Containing Transmembrane-1 | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.1371/journal.pone.0012535 | - |
dc.citation.journaltitle | PLoS ONE | - |
dc.identifier.wosid | 000281480900018 | - |
dc.identifier.scopusid | 2-s2.0-77958601292 | - |
dc.citation.number | 9 | - |
dc.citation.startpage | e12535 | - |
dc.citation.volume | 5 | - |
dc.identifier.sci | 000281480900018 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | RAS NULL MICE | - |
dc.subject.keywordPlus | CELL-CYCLE PROGRESSION | - |
dc.subject.keywordPlus | AEROSOL DELIVERY | - |
dc.subject.keywordPlus | MAMMALIAN TARGET | - |
dc.subject.keywordPlus | MITOCHONDRIA | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | PATHWAY | - |
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