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AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53
DC Field | Value | Language |
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dc.contributor.author | Han, Jung Min | - |
dc.contributor.author | Park, Bum-Joon | - |
dc.contributor.author | Park, Sang Gyu | - |
dc.contributor.author | Oh, Young Sun | - |
dc.contributor.author | Choi, So Jung | - |
dc.contributor.author | Lee, Sang Won | - |
dc.contributor.author | Hwang, Soon-Kyung | - |
dc.contributor.author | Chang, Seung-Hee | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.contributor.author | Kim, Sunghoon | - |
dc.date.accessioned | 2021-01-31T08:49:56Z | - |
dc.date.available | 2021-01-31T08:49:56Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2008-08 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America, Vol.105 No.32, pp.11206-11211 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.other | 3111 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172506 | - |
dc.description.abstract | AIMP2/p38 is a scaffolding protein required for the assembly of the macromolecular tRNA synthetase complex. Here, we describe a previously unknown function for AIMP2 as a positive regulator of p53 in response to genotoxic stresses. Depletion of AIMP2 increased resistance to DNA damage-induced apoptosis, and introduction of AIMP2 into AIMP2-deficient cells restored the susceptibility to apoptosis. Upon DNA damage, AIMP2 was phosphorylated, dissociated from the multi-tRNA synthetase complex, and translocated into the nuclei of cells. AIMP2 directly interacts with p53, thereby preventing MDM2-mediated ubiquitination and degradation of p53. Mutations in AIMP2, affecting its interaction with p53, hampered its ability to activate p53. Nutlin-3 recovered the level of p53 and the susceptibility to UV-induced cell death in AIMP2-deficient cells. This work demonstrates that AIMP2, a component of the translational machinery, functions as proapoptotic factor via p53 in response to DNA damage. | - |
dc.language | 영어 | - |
dc.publisher | National Academy of Sciences | - |
dc.title | AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53 | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.identifier.doi | 10.1073/pnas.0800297105 | - |
dc.citation.journaltitle | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.identifier.wosid | 000258560700033 | - |
dc.identifier.scopusid | 2-s2.0-49649116700 | - |
dc.citation.endpage | 11211 | - |
dc.citation.number | 32 | - |
dc.citation.startpage | 11206 | - |
dc.citation.volume | 105 | - |
dc.identifier.sci | 000258560700033 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.contributor.affiliatedAuthor | Kim, Sunghoon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | HISTONE DEACETYLASE | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | P43 | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | TRANSLATION | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordAuthor | aminoacyl-tRNA synthetase | - |
dc.subject.keywordAuthor | JNK | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | DNA damage | - |
dc.subject.keywordAuthor | mdm2 | - |
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