Analysis of urinary S-phenylmercapturic acid and trans,trans-muconic acid as exposure biomarkers of benzene in petrochemical and industrial areas of Korea

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Fang, MZ; Shin, MK; Park, KW; Kim, YS; Lee, JW; Cho, MH

Issue Date
Nordic Association of Occupational Safety and Health (NOROSH)
Scandinavian Journal of Work, Environment and Health, Vol.26 No.1, pp.62-66
Objectives Recently, S-phenylmercapturic acid (S-PMA) and trans,trans-muconic acid (t,t-MA) in urine have been proposed as reliable biomarkers for monitoring occupational exposure to benzene. The aim of this study was to test the applicability of S-PMA and t,t-MA as exposure biomarkers and to monitor the occupational exposure level and the extent of environmental contamination from benzene in Korea. Methods The urinary excretion of S-PMA and t,t-MA in rats after the intraperitoneal administration of benzene (0.88 similar to 800 mg/kg body weight, 7 days) was examined. These biomarkers were also validated in human urine samples collected from elementary schoolchildren in several industrial areas including chemical manufacturing plants, oil refineries, and natural gas-producing installations in Korea. Urine was collected from elementary schoolchildren in a mountain village with no known occupational exposure to benzene and air pollution as the reference group. Results In rats, there was a significant relationship between the benzene concentration and the excretion of the urinary S-PMA and t,t-MA as a function of concentration, and the excretion of benzene metabolites peaked on the first day after intraperitoneal administration. In human urine, higher levels of S-PMA and t,t-MA were detected more frequently in petrochemical industrial areas than in areas with no known occupational exposure to benzene. Conclusions These results show that the quantitative determination of S-PMA and t,t-MA in urine can be used as a reliable exposure biomarker for benzene, and they also suggest that extensive attention to benzene exposure is needed for maintaining the health of the population in Korea.
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College of Pharmacy (약학대학)Dept. of Manufacturing Pharmacy (제약학과)Journal Papers (저널논문_제약학과)
College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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