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Effects of carnosine and related compounds on monosaccharide autoxidation and H2O2 formation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Beom Jun | - |
dc.contributor.author | Kang, Kyung Sun | - |
dc.contributor.author | Nam, Sang Yoon | - |
dc.contributor.author | Park, Jae Hak | - |
dc.contributor.author | Lee, Yong Soon | - |
dc.contributor.author | Yun, Young Won | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.date.accessioned | 2021-01-31T08:50:12Z | - |
dc.date.available | 2021-01-31T08:50:12Z | - |
dc.date.created | 2020-12-16 | - |
dc.date.created | 2020-12-16 | - |
dc.date.issued | 1999-06 | - |
dc.identifier.citation | The Korean Journal of Physiology & Pharmacology, Vol.3 No.3, pp.251-261 | - |
dc.identifier.issn | 1226-4512 | - |
dc.identifier.other | 119227 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172510 | - |
dc.description.abstract | The effects of carnosine and related compounds (CRCs) including anserine, homocarnosine, histidine, and β-alanine on monosaccharide autoxidation and H2O2 formation were investigated. The incubation of CRCs with D-glucose, D-glucosamine, and D, L-glyceraldehyde at 37°C increased the absorption maxima at 285 nm, 273 nm, and 290~330 nm, respectively. D, L- glyceraldehyde was the most reactive sugar with CRCs. The presence of copper strongly stimulated the reaction of carnosine and anserine with D-glucose or D-glucosamine. Carnosine and anserine stimulated H2O2 formation from D- glucose autoxidation in a dose-dependent manner in the presence of 10 μM Cu (II). The presence of human serum albumin (HSA) decreased their effect on H2O2 formation. Carnosine and anserine has a biphasic effect on α- ketoaldehyde formation from glucose autoxidation, CRCs inhibited glycation of HSA as determined by hydroxymethyl furfural, lysine residue with free ε- amino group, and fructosamine assay. These results suggest that CRCs may be protective against diabetic complications by reacting with sugars and protecting glycation of protein. | - |
dc.language | 영어 | - |
dc.publisher | 대한약리학회 | - |
dc.title | Effects of carnosine and related compounds on monosaccharide autoxidation and H2O2 formation | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 조명행 | - |
dc.citation.journaltitle | The Korean Journal of Physiology & Pharmacology | - |
dc.identifier.scopusid | 2-s2.0-0032775108 | - |
dc.citation.endpage | 261 | - |
dc.citation.number | 3 | - |
dc.citation.startpage | 251 | - |
dc.citation.volume | 3 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kang, Kyung Sun | - |
dc.contributor.affiliatedAuthor | Park, Jae Hak | - |
dc.contributor.affiliatedAuthor | Lee, Yong Soon | - |
dc.contributor.affiliatedAuthor | Cho, Myung-Haing | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | aldehyde derivative | - |
dc.subject.keywordPlus | anserine | - |
dc.subject.keywordPlus | beta alanine | - |
dc.subject.keywordPlus | carnosine | - |
dc.subject.keywordPlus | copper | - |
dc.subject.keywordPlus | fructosamine | - |
dc.subject.keywordPlus | furfural | - |
dc.subject.keywordPlus | glucosamine | - |
dc.subject.keywordPlus | glucose | - |
dc.subject.keywordPlus | glyceraldehyde | - |
dc.subject.keywordPlus | histidine | - |
dc.subject.keywordPlus | homocarnosine | - |
dc.subject.keywordPlus | human serum albumin | - |
dc.subject.keywordPlus | hydrogen peroxide | - |
dc.subject.keywordPlus | lysine | - |
dc.subject.keywordPlus | monosaccharide | - |
dc.subject.keywordPlus | thiobarbituric acid derivative | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | autooxidation | - |
dc.subject.keywordPlus | chemical reaction | - |
dc.subject.keywordPlus | complication | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | diabetes mellitus | - |
dc.subject.keywordPlus | drug effect | - |
dc.subject.keywordPlus | glycation | - |
dc.subject.keywordAuthor | α-ketoaldehyde | - |
dc.subject.keywordAuthor | Antioxidant | - |
dc.subject.keywordAuthor | Carnosine and related compounds | - |
dc.subject.keywordAuthor | Free radicals | - |
dc.subject.keywordAuthor | Glucose oxidation | - |
dc.subject.keywordAuthor | Glycation | - |
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