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Subchronic Inhalation Toxicity of Silver Nanoparticles

Cited 307 time in Web of Science Cited 348 time in Scopus
Authors
Sung, Jae Hyuck; Ji, Jun Ho; Park, Jung Duck; Yoon, Jin Uk; Kim, Dae Sung; Jeon, Ki Soo; Song, Moon Yong; Jeong, Jayoung; Han, Beom Seok; Han, Jeong Hee; Chung, Yong Hyun; Chang, Hee Kyung; Lee, Ji Hyun; Cho, Myung-Haing; Kelman, Bruce J.; Yu, Il Je
Issue Date
2009-04
Citation
Toxicological Sciences, Vol.108 No.2, pp.452-461
Keywords
lungnanoparticles
Abstract
The subchronic inhalation toxicity of silver nanoparticles was studied in Sprague-Dawley rats. Eight-week- old rats, weighing approximately 253.2 g (males) and 162.6 g (females), were divided into four groups (10 rats in each group): fresh-air control, low dose (0.6 x 10(6) particle/cm(3), 49 mu g/m(3)), middle dose (1.4 x 10(6) particle/cm(3), 133 mu g/m(3)), and high dose (3.0 x 10(6) particle/cm(3), 515 mu g/m(3)). The animals were exposed to silver nanoparticles (average diameter 18-19 nm) for 6 h/day, 5 days/week, for 13 weeks in a whole-body inhalation chamber. In addition to mortality and clinical observations, body weight, food consumption, and pulmonary function tests were recorded weekly. At the end of the study, the rats were subjected to a full necropsy, blood samples were collected for hematology and clinical chemistry tests, and the organ weights were measured. Bile-duct hyperplasia in the liver increased dose dependently in both the male and female rats. Histopathological examinations indicated dose-dependent increases in lesions related to silver nanoparticle exposure, including mixed inflammatory cell infiltrate, chronic alveolar inflammation, and small granulomatous lesions. Target organs for silver nanoparticles were considered to be the lungs and liver in the male and female rats. No observable adverse effect level of 100 mu g/m(3) is suggested from the experiments.
ISSN
1096-6080
URI
https://hdl.handle.net/10371/172512
DOI
https://doi.org/10.1093/toxsci/kfn246
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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