Detailed Information

Subchronic Inhalation Toxicity of Silver Nanoparticles

Cited 364 time in Web of Science Cited 425 time in Scopus

Sung, Jae Hyuck; Ji, Jun Ho; Park, Jung Duck; Yoon, Jin Uk; Kim, Dae Sung; Jeon, Ki Soo; Song, Moon Yong; Jeong, Jayoung; Han, Beom Seok; Han, Jeong Hee; Chung, Yong Hyun; Chang, Hee Kyung; Lee, Ji Hyun; Cho, Myung Haing; Kelman, Bruce J.; Yu, Il Je

Issue Date
Oxford University Press
Toxicological Sciences, Vol.108 No.2, pp.452-461
The subchronic inhalation toxicity of silver nanoparticles was studied in Sprague-Dawley rats. Eight-week- old rats, weighing approximately 253.2 g (males) and 162.6 g (females), were divided into four groups (10 rats in each group): fresh-air control, low dose (0.6 x 10(6) particle/cm(3), 49 mu g/m(3)), middle dose (1.4 x 10(6) particle/cm(3), 133 mu g/m(3)), and high dose (3.0 x 10(6) particle/cm(3), 515 mu g/m(3)). The animals were exposed to silver nanoparticles (average diameter 18-19 nm) for 6 h/day, 5 days/week, for 13 weeks in a whole-body inhalation chamber. In addition to mortality and clinical observations, body weight, food consumption, and pulmonary function tests were recorded weekly. At the end of the study, the rats were subjected to a full necropsy, blood samples were collected for hematology and clinical chemistry tests, and the organ weights were measured. Bile-duct hyperplasia in the liver increased dose dependently in both the male and female rats. Histopathological examinations indicated dose-dependent increases in lesions related to silver nanoparticle exposure, including mixed inflammatory cell infiltrate, chronic alveolar inflammation, and small granulomatous lesions. Target organs for silver nanoparticles were considered to be the lungs and liver in the male and female rats. No observable adverse effect level of 100 mu g/m(3) is suggested from the experiments.
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Related Researcher

  • College of Veterinary Medicine
  • Department of Veterinary Medicine
Research Area Nanotoxicology, Veterinary Toxicology


Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.