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Comparing the toxic mechanism of synthesized zinc oxide nanomaterials by physicochemical characterization and reactive oxygen species properties

Cited 37 time in Web of Science Cited 39 time in Scopus
Authors
Park, Soo Jin; Park, Young Chan; Lee, Sang Won; Jeong, Min Sook; Yu, Kyeong-Nam; Jung, Haksung; Lee, Jin-Kyu; Kim, Jun Sung; Cho, Myung-Haing
Issue Date
2011-12
Citation
Toxicology Letters, Vol.207 No.3, pp.197-203
Keywords
ZnO nanomaterialsToxicityPhysicochemical characteristicsReactive oxygen species
Abstract
We studied the toxicity of ZnO nanomaterials in terms of physicochemical characteristics and reactive oxygen species (ROS) properties. ZnO nanorods [synthesized at room temperature (ZnO-RT, length; 18.0 +/- 4.2 nm) and at 60 degrees C (ZnO-60, length; 80.5 +/- 6.8 nm)] were used to evaluate the potential toxicity upon growth velocity-related particle size. The cytotoxicity of ZnO-60 was higher than that of ZnO-RT. We observed that the toxicity of ZnO-RT and ZnO-60 was related with ROS formation by using antioxidant N-acetylcysteine and electron spin resonance. Also, we found that the source of toxicity was not related to Zn2+ ions released from ZnO in 24 h treatment. Our results indicate that toxicity of ZnO nanorods is caused by the amounts of ROS. Our study strongly suggests that size of nanomaterial is not the sole factor to be considered, thus, the development of appropriate criteria based on morphological/physicochemical characteristics as well as synthesis procedures is needed to evaluate the precise toxicity. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
ISSN
0378-4274
URI
https://hdl.handle.net/10371/172526
DOI
https://doi.org/10.1016/j.toxlet.2011.09.011
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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