Publications

Detailed Information

One-month parenteral toxicity study of recombinant human basic fibroblast growth factor in dogs

Cited 1 time in Web of Science Cited 1 time in Scopus
Authors

Kim, MY; Shin, MK; Son, JW; Kwak, HI; Fang, MZ; Bae, MO; Kim, JH; Cho, MH; Kang, KK; Kim, WB; Ahn, BO

Issue Date
2000-08
Publisher
Comparative Toxicology Laboratories
Citation
Veterinary and Human Toxicology, Vol.42 No.4, pp.234-235
Abstract
A 1-mo toxicity study followed by a 1-mo recovery period of recombinant human basic fibroblast growth factor (bFGF) was performed using Beagle dogs at doses of 30, 120 or 480 mg/kg/d to estimate the no observed adverse effect level (NOAEL). Subcutaneous thickening was seen and its incidence, as well as that of stiffness of the injection sites, increased with dose. There were neither dead animals nor significant changes of body weight during the experimental period. In addition, no significant bFGF-related changes were found in ophthalmologic and histopathological examination, urinalysis and hematological, biochemical and organ weight parameters. At necropsy, red-brownish spots and/or nodule formations were recognized in a dose-dependent manner. Splenomegaly was noted in the 480 mg/kg group, but these findings had a low incidence in all dose groups. The findings in the dosing period disappeared or were ameliorated during the recovery period. The above data suggests the NOAEL of bFGF in Beagle dogs is >480 mg/kg/d.
ISSN
0145-6296
URI
https://hdl.handle.net/10371/172531
Files in This Item:
There are no files associated with this item.
Appears in Collections:

Related Researcher

  • College of Veterinary Medicine
  • Department of Veterinary Medicine
Research Area Nanotoxicology, Veterinary Toxicology

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share