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Acute pulmonary toxicity and body distribution of inhaled metallic silver nanoparticles

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Authors
Kwon, Jung-Taek; Minai-Tehrani, Arash Minai; Hwang, Soon-Kyung; Kim, Ji-Eun; Shin, Ji-Young; Yu, Kyeong-Nam; Chang, Seung-Hee; Kim, Dae-Seong; Kwon, Yong-Taek; Choi, In-Ja; Cheong, Yun-Hee; Kim, Jun Sung; Cho, Myung-Haing
Issue Date
2012-03
Citation
한국독성학회지, Vol.28 No.1, pp.25-31
Abstract
The purpose of this study was to determine the acute pulmonary toxicity of metallic silver nanoparticles (MSNPs, 20.30 nm in diameter). Acute pulmonary toxicity and body distribution of inhaled MSNPs in mice were evaluated using a nose-only exposure chamber (NOEC) system. Bronchoalveolar lavage (BAL) fluid analysis, Western blotting, histopathological changes, and silver burdens in various organs were determined in mice. Mice were exposed to MSNPs for 6 hrs. The mean concentration, total surface area, volume and mass concentrations in the NOEC were maintained at 1.93 × 107 particles/cm3, 1.09 × 1010 nm2/cm3, 2.72 × 1011 nm3/cm3, and 2854.62 μg/m3, respectively. Inhalation of MSPNs caused mild pulmonary toxicity with distribution of silver in various organs but the silver burdens decreased rapidly at 24-hrs post-exposure in the lung. Furthermore, inhaled MSNPs induced activation of mitogen-activated protein kinase (MAPK) signaling in the lung. In summary, single inhaled MSNPs caused mild pulmonary toxicity, which was associated with activated MAPK signaling. Taken together, our results suggest that the inhalation toxicity of MSNPs should be carefully considered at the molecular level.
ISSN
1976-8257
URI
https://hdl.handle.net/10371/172539
DOI
https://doi.org/10.5487/TR.2012.28.1.025
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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