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Modulation of cancer cell growth and progression by Caveolin-1 in the tumor microenvironment

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Authors
Yoon, Hyo-Jin; Surh, Young-Joon
Issue Date
2020-01
Citation
Advances in Experimental Medicine and Biology, Vol.1277, pp.63-74
Keywords
Caveolin-1CaveolaeCancer-associated fibroblastsCancer progressionCancer stem-like cellsEpithelial-mesenchymal transitionMetastasisStem cellsStromal cellsTumor microenvironment
Abstract
Caveolin-1 (Cav-1), a major structural component of cell membrane caveolae, is involved in a variety of intracellular signaling pathways as well as transmembrane transport. Cav-1, as a scaffolding protein, modulates signal transduction associated with cell cycle progression, cellular senescence, cell proliferation and death, lipid homeostasis, etc. Cav-1 is also thought to regulate the expression or activity of oncoproteins, such as Src family kinases, H-Ras, protein kinase C, epidermal growth factor, extracellular signal-regulated kinase, and endothelial nitric oxide synthase. Because of its frequent overexpression or mutation in various tumor tissues and cancer cell lines, Cav-1 has been speculated to play a role as an oncoprotein in cancer development and progression. In contrast, Cav-1 may also function as a tumor suppressor, depending on the type of cancer cells and/or surrounding -stromal cells in the tumor microenvironment as well as the stage of tumors.
ISSN
0065-2598
URI
https://hdl.handle.net/10371/172545
DOI
https://doi.org/10.1007/978-3-030-50224-9_4
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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