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Cancer chemopreventive effects of curcumin
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Surh, Young-Joon | - |
dc.contributor.author | Chun, Kyung-Soo | - |
dc.date.accessioned | 2021-01-31T09:17:48Z | - |
dc.date.available | 2021-01-31T09:17:48Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Advances in Experimental Medicine and Biology, Vol.595, pp.149-172 | - |
dc.identifier.issn | 0065-2598 | - |
dc.identifier.other | 3573 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172548 | - |
dc.description.abstract | Chemoprevention, which is referred to as the use of nontoxic natural or synthetic chemicals to intervene in multistage carcinogenesis, has emerged as a promising and pragmatic medical approach to reduce the risk of cancer. Numerous components of edible plants, collectively termed "phytochemicals" have been reported to possess substantial chemopreventive properties. Curcumin, a yellow coloring ingredient derived from Curcuma longa L. (Zingiberaceae), is one of the most extensively investigated and well-defined chemopreventive phytochemicals. Curcumin has been shown to protect against skin, oral, intestinal, and colon carcinogenesis and also to suppress angiogenesis and metastasis in a variety animal tumor models. It also inhibits the proliferation of cancer cells by arresting them in the various phases of the cell cycle and by inducing apoptosis. Moreover, curcumin has a capability to inhibit carcinogen bioactivation via suppression of specific cytochrome P450 isozymes, as well as to induce the activity or expression of phase II carcinogen detoxifying enzymes. Well-designed intervention studies are necessary to assess the chemopreventive efficacy of curcumin in normal individuals as well as high-risk groups. Sufficient data from pharmacodynamic as well as mechanistic studies are necessary to advocate clinical evaluation of curcumin for its chemopreventive potential. | - |
dc.language | 영어 | - |
dc.publisher | Kluwer Academic/Plenum Publishers | - |
dc.title | Cancer chemopreventive effects of curcumin | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1007/978-0-387-46401-5_5 | - |
dc.citation.journaltitle | Advances in Experimental Medicine and Biology | - |
dc.identifier.wosid | 000246951600005 | - |
dc.identifier.scopusid | 2-s2.0-84934442428 | - |
dc.citation.endpage | 172 | - |
dc.citation.startpage | 149 | - |
dc.citation.volume | 595 | - |
dc.identifier.sci | 000246951600005 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | 12-O-TETRADECANOYLPHORBOL-13-ACETATE-INDUCED TUMOR PROMOTION | - |
dc.subject.keywordPlus | FAMILIAL ADENOMATOUS POLYPOSIS | - |
dc.subject.keywordPlus | INHIBITS CELL-PROLIFERATION | - |
dc.subject.keywordPlus | BREAST-CARCINOMA CELLS | - |
dc.subject.keywordPlus | B16F10 MELANOMA-CELLS | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | HUMAN PROSTATE-CANCER | - |
dc.subject.keywordPlus | I CLINICAL-TRIAL | - |
dc.subject.keywordPlus | BCL-X-L | - |
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