S-Space Graduate School of Convergence Science and Technology (융합과학기술대학원) Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과) Journal Papers (저널논문_분자의학 및 바이오제약학과)
Lack of tumor promoting activity of capsaicin, a principal pungent ingredient of red pepper, in mouse skin carcinogenesis
- Park, K. K.; Chun, K. S.; Yook, J. I.; Surh, Young-Joon
- Issue Date
- Anticancer Research, Vol.18 No.6A, pp.4201-4205
- capsaicin; hot red pepper; anti-tumor promotion; ornithine decarboxylase; two-stage mouse skin carcinogenesis
- Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is the major pungent principle of hot peppers of the genus Capsicum. There have been numerous investigations to evaluate the effects of capsaicin on experimental carcinogenesis and mutagenesis, bur the results are discordant. In the present study, we have assessed the tumor promoting potential of capsaicin using a two stage mouse skin carcinogenesis model. Repeated applications of capsaicin (10 mu mol) onto the shaven back of female ICR mice following a single-initiation dose of 7,12-dimethylbenz[alpha]anthracene did not cause any significant increase- in papilloma formation and abnormal hyperplastic or inflammatory skin lesions, compared with the solvent control Furthermore, the topical application of capsaicin did not induce the epidermal ornithine decarboxylase activity, suggesting that it lacks tumor-promotional activity. On the contrary, the compound ameliorated the mouse skin carcinogenesis wizen given simultaneously with the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate.
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