Browse

Lack of tumor promoting activity of capsaicin, a principal pungent ingredient of red pepper, in mouse skin carcinogenesis

Cited 0 time in Web of Science Cited 0 time in Scopus
Authors
Park, K. K.; Chun, K. S.; Yook, J. I.; Surh, Young-Joon
Issue Date
1998-11
Citation
Anticancer Research, Vol.18 No.6A, pp.4201-4205
Keywords
capsaicinhot red pepperanti-tumor promotionornithine decarboxylasetwo-stage mouse skin carcinogenesis
Abstract
Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is the major pungent principle of hot peppers of the genus Capsicum. There have been numerous investigations to evaluate the effects of capsaicin on experimental carcinogenesis and mutagenesis, bur the results are discordant. In the present study, we have assessed the tumor promoting potential of capsaicin using a two stage mouse skin carcinogenesis model. Repeated applications of capsaicin (10 mu mol) onto the shaven back of female ICR mice following a single-initiation dose of 7,12-dimethylbenz[alpha]anthracene did not cause any significant increase- in papilloma formation and abnormal hyperplastic or inflammatory skin lesions, compared with the solvent control Furthermore, the topical application of capsaicin did not induce the epidermal ornithine decarboxylase activity, suggesting that it lacks tumor-promotional activity. On the contrary, the compound ameliorated the mouse skin carcinogenesis wizen given simultaneously with the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate.
ISSN
0250-7005
URI
https://hdl.handle.net/10371/172550
Files in This Item:
There are no files associated with this item.
Appears in Collections:
Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse