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15-Deoxy-Δ12,14-Prostaglandin J2 Exerts Proresolving Effects Through Nuclear Factor E2-Related Factor 2-Induced Expression of CD36 and Heme Oxygenase-1 : 15-Deoxy-(12,14)-Prostaglandin J(2) Exerts Proresolving Effects Through Nuclear Factor E2-Related Factor 2-Induced Expression of CD36 and Heme Oxygenase-1
DC Field | Value | Language |
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dc.contributor.author | Kim, Wonki | - |
dc.contributor.author | Lee, Ha-Na | - |
dc.contributor.author | Jang, Jeong-Hoon | - |
dc.contributor.author | Kim, Seung Hyeon | - |
dc.contributor.author | Lee, Yeon-Hwa | - |
dc.contributor.author | Hahn, Young-Il | - |
dc.contributor.author | Ngo, Hoang-Kieu-Chi | - |
dc.contributor.author | Choi, Yeonseo | - |
dc.contributor.author | Joe, Yeonsoo | - |
dc.contributor.author | Chung, Hun Taeg | - |
dc.contributor.author | Chen, Yingqing | - |
dc.contributor.author | Cha, Young Nam | - |
dc.contributor.author | Surh, Young Joon | - |
dc.date.accessioned | 2021-01-31T09:18:23Z | - |
dc.date.available | 2021-01-31T09:18:23Z | - |
dc.date.created | 2018-08-10 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.citation | Antioxidants and Redox Signaling, Vol.27 No.17, pp.1412-1431 | - |
dc.identifier.issn | 1523-0864 | - |
dc.identifier.other | 42872 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172556 | - |
dc.description.abstract | Aims: 15-Deoxy-(12,14)-prostaglandin J(2) (15d-PGJ(2)) has been shown to rescue cells from inflammatory insults and to participate in the resolution of acute inflammation. In this study, we investigated molecular mechanisms underlying proresolving effects of 15d-PGJ(2). Results: 15d-PGJ(2) injected into the peritoneum of mice facilitated the resolution of zymosan A-induced peritonitis. 15d-PGJ(2) administration reduced the number of total leukocytes and attenuated polymorphonuclear leukocyte infiltration. Furthermore, 15d-PGJ(2) increased the proportion of macrophages engulfing apoptotic neutrophils, a process called efferocytosis. In addition, when the thioglycollate-elicited mouse peritoneal macrophages were stimulated with 15d-PGJ(2), their efferocytic activity was amplified. In another experiment, RAW264.7 murine macrophages exposed to 15d-PGJ(2) conducted phagocytic clearance of apoptotic cells to a greater extent than the control cells. Under these conditions, expression of CD36 and heme oxygenase-1 (HO-1) was enhanced along with increased accumulation of the nuclear factor E2-related factor 2 (Nrf2) in the nucleus. Knockdown of Nrf2 abolished 15d-PGJ(2)-induced expression of CD36 and HO-1, and silencing of CD36 and HO-1 attenuated 15d-PGJ(2)-induced efferocytosis. Moreover, peritoneal macrophages isolated from Nrf2-null mice failed to upregulate 15d-PGJ(2)-induced expression of CD36 and HO-1 and to mediate efferocytosis. Unlike 15d-PGJ(2), its nonelectrophilic analog 9,10-dihydro-15d-PGJ(2) lacking the ,-unsaturated carbonyl group could not induce CD36 expression and efferocytosis. Innovation: 15d-PGJ(2), as one of the terminal products of cyclooxygenase-2, exerts proresolving effects through induction of efferocytosis. The results of this study suggest that 15d-PGJ(2) possesses a therapeutic value in the management of inflammatory disorders. Conclusion: 15d-PGJ(2) facilitates resolution of inflammation by inducing Nrf2-induced expression of CD36 and HO-1 in macrophages. Antioxid. | - |
dc.language | 영어 | - |
dc.publisher | Mary Ann Liebert Inc. | - |
dc.title | 15-Deoxy-Δ12,14-Prostaglandin J2 Exerts Proresolving Effects Through Nuclear Factor E2-Related Factor 2-Induced Expression of CD36 and Heme Oxygenase-1 | - |
dc.title.alternative | 15-Deoxy-(12,14)-Prostaglandin J(2) Exerts Proresolving Effects Through Nuclear Factor E2-Related Factor 2-Induced Expression of CD36 and Heme Oxygenase-1 | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1089/ars.2016.6754 | - |
dc.citation.journaltitle | Antioxidants and Redox Signaling | - |
dc.identifier.wosid | 000413848400003 | - |
dc.identifier.scopusid | 2-s2.0-85032629852 | - |
dc.citation.endpage | 1431 | - |
dc.citation.number | 17 | - |
dc.citation.startpage | 1412 | - |
dc.citation.volume | 27 | - |
dc.identifier.sci | 000413848400003 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR NRF2 | - |
dc.subject.keywordPlus | ACTIVATED RECEPTOR-GAMMA | - |
dc.subject.keywordPlus | 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J(2) | - |
dc.subject.keywordPlus | MURINE MACROPHAGES | - |
dc.subject.keywordPlus | APOPTOTIC CELLS | - |
dc.subject.keywordPlus | LIPID MEDIATORS | - |
dc.subject.keywordPlus | CARBON-MONOXIDE | - |
dc.subject.keywordPlus | ACUTE-INFLAMMATION | - |
dc.subject.keywordPlus | RESPONSE ELEMENTS | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordAuthor | 15-deoxy-12 | - |
dc.subject.keywordAuthor | 14-prostaglandin J(2) | - |
dc.subject.keywordAuthor | efferocytosis | - |
dc.subject.keywordAuthor | heme oxygenase-1 | - |
dc.subject.keywordAuthor | Nrf2 | - |
dc.subject.keywordAuthor | resolution of inflammation | - |
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