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Resveratrol suppresses gastric cancer cell proliferation and survival through inhibition of PIM-1 kinase activity

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dc.contributor.authorKim, Sujin-
dc.contributor.authorKim, Wonki-
dc.contributor.authorKim, Do-Hee-
dc.contributor.authorJang, Jeong-Hoon-
dc.contributor.authorKim, Su-Jung-
dc.contributor.authorPark, Sin-Aye-
dc.contributor.authorHahn, Hyunggu-
dc.contributor.authorHan, Byung Woo-
dc.contributor.authorNa, Hye-Kyung-
dc.contributor.authorChun, Kyung-Soo-
dc.contributor.authorChoi, Bu Young-
dc.contributor.authorSurh, Young-Joon-
dc.date.accessioned2021-01-31T09:19:15Z-
dc.date.available2021-01-31T09:19:15Z-
dc.date.issued2020-08-
dc.identifier.citationArchives of Biochemistry and Biophysics, Vol.689, p. 108413-
dc.identifier.issn0003-9861-
dc.identifier.other108185-
dc.identifier.urihttps://hdl.handle.net/10371/172568-
dc.description.abstractThe proviral integration site for Moloney murine leukemia virus (PIM) family of serine/threonine-specific kinases consist of three isoforms, that regulate proliferation, apoptosis, metabolism, invasion, and metastasis of cancer cells. Among these, abnormally elevated kinase activity of PIM-1 contributes to the progression of gastric cancer and predicts poor prognosis and a low survival rate in gastric cancer patients. In the present study, we found that resveratrol, one of the representative chemopreventive and anticarcinogenic phytochemicals, directly binds to PIM-1 and thereby inhibits its catalytic activity in human gastric cancer SNU-601 cells. This resulted in suppression of phosphorylation of the proapoptotic Bad, a known substrate of PIM-1. Resveratrol, by inactivating PIM-1, also inhibited anchorage-independent growth and proliferation of SNU-601 cells. To understand the molecular interaction between resveratrol and PIM-1, we conducted docking simulation and found that resveratrol directly binds to the PIM-1 at the ATP-binding pocket. In conclusion, the proapototic and anti-proliferative effects of resveratrol in gastric cancer cells are likely to be mediated through suppression of PIM-1 kinase activity, which may represent a novel mechanism underlying its chemopreventive and anticarcinogenic actions.-
dc.subjectResveratrol-
dc.subjectPIM-1-
dc.subjectCancer chemoprevention-
dc.subjectGastric cancer-
dc.titleResveratrol suppresses gastric cancer cell proliferation and survival through inhibition of PIM-1 kinase activity-
dc.typeArticle-
dc.contributor.AlternativeAuthor서영준-
dc.identifier.doi10.1016/j.abb.2020.108413-
dc.citation.journaltitleArchives of Biochemistry and Biophysics-
dc.identifier.scopusid2-s2.0-85087514963-
dc.citation.startpage108413-
dc.citation.volume689-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0003986120304227?via%3Dihub-
dc.identifier.rimsid108185-
dc.identifier.sci000549359300007-
dc.description.isOpenAccessY-
dc.contributor.affiliatedAuthorSurh, Young-Joon-
Appears in Collections:
Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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