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Resveratrol suppresses gastric cancer cell proliferation and survival through inhibition of PIM-1 kinase activity
DC Field | Value | Language |
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dc.contributor.author | Kim, Sujin | - |
dc.contributor.author | Kim, Wonki | - |
dc.contributor.author | Kim, Do-Hee | - |
dc.contributor.author | Jang, Jeong-Hoon | - |
dc.contributor.author | Kim, Su-Jung | - |
dc.contributor.author | Park, Sin-Aye | - |
dc.contributor.author | Hahn, Hyunggu | - |
dc.contributor.author | Han, Byung Woo | - |
dc.contributor.author | Na, Hye-Kyung | - |
dc.contributor.author | Chun, Kyung-Soo | - |
dc.contributor.author | Choi, Bu Young | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T09:19:15Z | - |
dc.date.available | 2021-01-31T09:19:15Z | - |
dc.date.created | 2020-07-22 | - |
dc.date.created | 2020-07-22 | - |
dc.date.issued | 2020-08 | - |
dc.identifier.citation | Archives of Biochemistry and Biophysics, Vol.689, p. 108413 | - |
dc.identifier.issn | 0003-9861 | - |
dc.identifier.other | 108185 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172568 | - |
dc.description.abstract | The proviral integration site for Moloney murine leukemia virus (PIM) family of serine/threonine-specific kinases consist of three isoforms, that regulate proliferation, apoptosis, metabolism, invasion, and metastasis of cancer cells. Among these, abnormally elevated kinase activity of PIM-1 contributes to the progression of gastric cancer and predicts poor prognosis and a low survival rate in gastric cancer patients. In the present study, we found that resveratrol, one of the representative chemopreventive and anticarcinogenic phytochemicals, directly binds to PIM-1 and thereby inhibits its catalytic activity in human gastric cancer SNU-601 cells. This resulted in suppression of phosphorylation of the proapoptotic Bad, a known substrate of PIM-1. Resveratrol, by inactivating PIM-1, also inhibited anchorage-independent growth and proliferation of SNU-601 cells. To understand the molecular interaction between resveratrol and PIM-1, we conducted docking simulation and found that resveratrol directly binds to the PIM-1 at the ATP-binding pocket. In conclusion, the proapototic and anti-proliferative effects of resveratrol in gastric cancer cells are likely to be mediated through suppression of PIM-1 kinase activity, which may represent a novel mechanism underlying its chemopreventive and anticarcinogenic actions. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | Resveratrol suppresses gastric cancer cell proliferation and survival through inhibition of PIM-1 kinase activity | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/j.abb.2020.108413 | - |
dc.citation.journaltitle | Archives of Biochemistry and Biophysics | - |
dc.identifier.wosid | 000549359300007 | - |
dc.identifier.scopusid | 2-s2.0-85087514963 | - |
dc.citation.startpage | 108413 | - |
dc.citation.volume | 689 | - |
dc.identifier.sci | 000549359300007 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Han, Byung Woo | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | SERINE/THREONINE KINASE | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | PROMOTES | - |
dc.subject.keywordPlus | STAT3 | - |
dc.subject.keywordAuthor | Resveratrol | - |
dc.subject.keywordAuthor | PIM-1 | - |
dc.subject.keywordAuthor | Cancer chemoprevention | - |
dc.subject.keywordAuthor | Gastric cancer | - |
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