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Resveratrol suppresses migration, invasion and sternness of human breast cancer cells by interfering with tumor-stromal cross-talk

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dc.contributor.authorSuh, Jinyoung-
dc.contributor.authorKim, Do-Hee-
dc.contributor.authorSurh, Young-Joon-
dc.date.accessioned2021-01-31T09:19:29Z-
dc.date.available2021-01-31T09:19:29Z-
dc.date.issued2018-04-
dc.identifier.citationArchives of Biochemistry and Biophysics, Vol.643, pp.62-71-
dc.identifier.issn0003-9861-
dc.identifier.other75104-
dc.identifier.urihttps://hdl.handle.net/10371/172571-
dc.description.abstractCancer-associated fibroblasts (CAFs) constitute a major compartment of the tumor microenvironment. CAFs produce a variety of cytokines, growth factors and extracellular matrix proteins, thereby stimulating tumor progression. CAFs are distinct from normal fibroblasts for their overexpression of a-smooth muscle actin. Recent studies suggest that CAFs play an important role in proliferation and migration of cancer cells through cross-talk with them. Resveratrol (trans-3,4'5,-trihydroxystilbene), a phytoalexin present in grapes, has been reported to possess chemopreventive and chemotherapeutic activities. In the present study, we examined the effects of resveratrol on CAF-induced migration, invasion and self-renewal activity of breast cancer cells. Resveratrol inhibited proliferation, migration and invasion of human breast cancer cells treated with CAF-conditioned media (CAF-CM). Resveratrol treatment suppressed the CAF-CM-induced expression of Cyclin D1, c-Myc, MMP-2 and MMP-9. In addition, resveratrol inhibited Sox2 expression as well as activation of Akt and STAT3 induced by CAF-CM in breast cancer cells. Further, resveratrol abrogated stemness properties and reduced the expression of self-renewal signaling molecules in stem-like breast cancer cells. Taken together, the present study provides insights into the role of resveratrol in tumor microenvironment with focus on interaction between cancer cells and the hosting niche.-
dc.subjectBreast cancer-
dc.subjectCancer-associated fibroblasts-
dc.subjectCancer stem cells-
dc.subjectResveratrol-
dc.subjectTumor microenvironment-
dc.titleResveratrol suppresses migration, invasion and sternness of human breast cancer cells by interfering with tumor-stromal cross-talk-
dc.typeArticle-
dc.contributor.AlternativeAuthor서영준-
dc.identifier.doi10.1016/j.abb.2018.02.011-
dc.citation.journaltitleArchives of Biochemistry and Biophysics-
dc.identifier.scopusid2-s2.0-85042754158-
dc.citation.endpage71-
dc.citation.startpage62-
dc.citation.volume643-
dc.identifier.url/www.sciencedirect.com/science/article/pii/S0003986117307282?via%3Dihub-
dc.identifier.rimsid75104-
dc.identifier.sci000430371800009-
dc.contributor.affiliatedAuthorSurh, Young-Joon-
Appears in Collections:
Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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