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Resveratrol suppresses migration, invasion and sternness of human breast cancer cells by interfering with tumor-stromal cross-talk
DC Field | Value | Language |
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dc.contributor.author | Suh, Jinyoung | - |
dc.contributor.author | Kim, Do-Hee | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T09:19:29Z | - |
dc.date.available | 2021-01-31T09:19:29Z | - |
dc.date.created | 2019-06-11 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.citation | Archives of Biochemistry and Biophysics, Vol.643, pp.62-71 | - |
dc.identifier.issn | 0003-9861 | - |
dc.identifier.other | 75104 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172571 | - |
dc.description.abstract | Cancer-associated fibroblasts (CAFs) constitute a major compartment of the tumor microenvironment. CAFs produce a variety of cytokines, growth factors and extracellular matrix proteins, thereby stimulating tumor progression. CAFs are distinct from normal fibroblasts for their overexpression of a-smooth muscle actin. Recent studies suggest that CAFs play an important role in proliferation and migration of cancer cells through cross-talk with them. Resveratrol (trans-3,4'5,-trihydroxystilbene), a phytoalexin present in grapes, has been reported to possess chemopreventive and chemotherapeutic activities. In the present study, we examined the effects of resveratrol on CAF-induced migration, invasion and self-renewal activity of breast cancer cells. Resveratrol inhibited proliferation, migration and invasion of human breast cancer cells treated with CAF-conditioned media (CAF-CM). Resveratrol treatment suppressed the CAF-CM-induced expression of Cyclin D1, c-Myc, MMP-2 and MMP-9. In addition, resveratrol inhibited Sox2 expression as well as activation of Akt and STAT3 induced by CAF-CM in breast cancer cells. Further, resveratrol abrogated stemness properties and reduced the expression of self-renewal signaling molecules in stem-like breast cancer cells. Taken together, the present study provides insights into the role of resveratrol in tumor microenvironment with focus on interaction between cancer cells and the hosting niche. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | Resveratrol suppresses migration, invasion and sternness of human breast cancer cells by interfering with tumor-stromal cross-talk | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/j.abb.2018.02.011 | - |
dc.citation.journaltitle | Archives of Biochemistry and Biophysics | - |
dc.identifier.wosid | 000430371800009 | - |
dc.identifier.scopusid | 2-s2.0-85042754158 | - |
dc.citation.endpage | 71 | - |
dc.citation.startpage | 62 | - |
dc.citation.volume | 643 | - |
dc.identifier.sci | 000430371800009 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | HUMAN LIVER MYOFIBROBLASTS | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | SELF-RENEWAL | - |
dc.subject.keywordPlus | MOLECULAR-MECHANISMS | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | FIBROBLASTS | - |
dc.subject.keywordPlus | MICROENVIRONMENT | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | POLYPHENOL | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordAuthor | Cancer-associated fibroblasts | - |
dc.subject.keywordAuthor | Cancer stem cells | - |
dc.subject.keywordAuthor | Resveratrol | - |
dc.subject.keywordAuthor | Tumor microenvironment | - |
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