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Rutin inhibits UVB radiation-induced expression of COX-2 and iNOS in hairless mouse skin: p38 MAP kinase and JNK as potential targets
DC Field | Value | Language |
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dc.contributor.author | Choi, Ki-Seok | - |
dc.contributor.author | Kundu, Joydeb Kumar | - |
dc.contributor.author | Chun, Kyung-Soo | - |
dc.contributor.author | Na, Hye-Kyung | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T09:19:47Z | - |
dc.date.available | 2021-01-31T09:19:47Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2014-10 | - |
dc.identifier.citation | Archives of Biochemistry and Biophysics, Vol.559, pp.38-45 | - |
dc.identifier.issn | 0003-9861 | - |
dc.identifier.other | 1217 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172575 | - |
dc.description.abstract | Exposure to ultraviolet B (UVB) radiation, a complete environmental carcinogen, induces oxidative and inflammatory skin damage, thereby increasing the risk of skin carcinogenesis. The antioxidant and anti-inflammatory activities of a wide variety of plant polyphenols have been reported. Rutin (3-rhamnosyl-glucosylquercetin), a polyphenol present in many edible plants, possesses diverse pharmacological properties including antioxidant, anti-inflammatory, antimutagenic and anticancer activities. The present study was aimed to investigate the effects of rutin on UVB-induced inflammation in mouse skin in vivo. Topical application of rutin onto the dorsal skin of female HR-1 hairless mice 30 min prior to UVB irradiation diminished epidermal hyperplasia and the levels of proteins modified by 4-hydroxynonenal, which is a biochemical hallmark of lipid peroxidation. Topical application of rutin also significantly inhibited UVB-induced expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), two representative inflammatory enzymes, in hairless mouse skin. Rutin inhibited the DNA binding of activator protein-1 (AP-1) and phosphorylation of signal transducer and activator of transcription-3 (STAT3) in mouse skin exposed to UVB. Moreover, rutin attenuated UVB-induced phosphorylation of p38 mitogen-activated protein (MAP) kinase and c-Jun-N-terminal kinase (JNK). Pharmacological inhibition of p38 MAP kinase and JNK decreased UVB-induced expression of COX-2 in mouse skin. Taken together, these findings suggest that rutin exerts anti-inflammatory effects in UVB-irradiated mouse skin by inhibiting expression of COX-2 and iNOS, which is attributable to its suppression of p38 MAP kinase and JNK signaling responsible for AP-1 activation. (C) 2014 Elsevier Inc. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | Rutin inhibits UVB radiation-induced expression of COX-2 and iNOS in hairless mouse skin: p38 MAP kinase and JNK as potential targets | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/j.abb.2014.05.016 | - |
dc.citation.journaltitle | Archives of Biochemistry and Biophysics | - |
dc.identifier.wosid | 000341073100007 | - |
dc.identifier.scopusid | 2-s2.0-84906791799 | - |
dc.citation.endpage | 45 | - |
dc.citation.startpage | 38 | - |
dc.citation.volume | 559 | - |
dc.identifier.sci | 000341073100007 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASES | - |
dc.subject.keywordPlus | ESTER-INDUCED EXPRESSION | - |
dc.subject.keywordPlus | PHORBOL ESTER | - |
dc.subject.keywordPlus | CYCLOOXYGENASE-2 EXPRESSION | - |
dc.subject.keywordPlus | UPSTREAM TARGETS | - |
dc.subject.keywordPlus | HUMAN KERATINOCYTES | - |
dc.subject.keywordPlus | OXIDATIVE DAMAGE | - |
dc.subject.keywordPlus | TERMINAL KINASE | - |
dc.subject.keywordAuthor | Rutin | - |
dc.subject.keywordAuthor | Cyclooxygenase-2 | - |
dc.subject.keywordAuthor | Inducible nitric oxide synthase | - |
dc.subject.keywordAuthor | Mouse skin carcinogenesis | - |
dc.subject.keywordAuthor | UVB-induced skin cancer | - |
dc.subject.keywordAuthor | AP-1 | - |
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