Publications
Detailed Information
Suppression of phorbol ester-induced NF-κB activation by capsaicin in cultured human promyelocytic leukemia cells : Suppression of phorbol ester-induced NF-kappa B activation by capsaicin in cultured human promyelocytic leukemia cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Seong-Su | - |
dc.contributor.author | Keum, Young-Sam | - |
dc.contributor.author | Chun, Kyung-Soo | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T09:20:12Z | - |
dc.date.available | 2021-01-31T09:20:12Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2002-08 | - |
dc.identifier.citation | Archives of Pharmacal Research, Vol.25 No.4, pp.475-479 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.other | 4623 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172581 | - |
dc.description.abstract | Capsaicin, a major pungent constituent of red pepper (Capsicum annuum L.) possesses a vast variety of pharmacologic and physiologic activities. Despite its irritant properties, the compound exerts anti-inflammatory and anti-nociceptive effects. Previous studies from this laboratory revealed that capsaicin, when topically applied onto dorsal skin of female ICR mice, strongly attenuated activation of NF-kappaB and AP-1 induced by the typical tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), which may account for its anti-tumor promoting activity in mouse skin. In the present work, we have found that capsaicin suppresses TPA-stimulated activation of NF-kappaB through inhibition of IkappaBalpha degradation and blockade of subsequent nuclear translocation of p65 in human promyelocytic leukemia HL-60 cells. Methylation of the phenolic hydroxyl group of capsaicin abolished its inhibitory effect on NF-kappaB DNA binding. Likewise, TPA-induced activation of AP-1 was mitigated by capsaicin treatment. | - |
dc.language | 영어 | - |
dc.publisher | 대한약학회 | - |
dc.title | Suppression of phorbol ester-induced NF-κB activation by capsaicin in cultured human promyelocytic leukemia cells | - |
dc.title.alternative | Suppression of phorbol ester-induced NF-kappa B activation by capsaicin in cultured human promyelocytic leukemia cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1007/BF02976605 | - |
dc.citation.journaltitle | Archives of Pharmacal Research | - |
dc.identifier.wosid | 000177881100014 | - |
dc.identifier.scopusid | 2-s2.0-0036689903 | - |
dc.citation.endpage | 479 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 475 | - |
dc.citation.volume | 25 | - |
dc.identifier.sci | 000177881100014 | - |
dc.identifier.kciid | ART000922713 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ANTIINFLAMMATORY ACTIVITY | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | GENE-TRANSCRIPTION | - |
dc.subject.keywordPlus | TRANSFORMED-CELLS | - |
dc.subject.keywordPlus | REDOX REGULATION | - |
dc.subject.keywordPlus | NADH-OXIDASE | - |
dc.subject.keywordPlus | FATTY-ACIDS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordAuthor | activator protein-1 (AP-1) | - |
dc.subject.keywordAuthor | capsaicin | - |
dc.subject.keywordAuthor | HL-60 cells | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | TPA | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.