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PharmDB-K: Integrated bio-pharmacological network database for traditional Korean medicine
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Ji-Hyun | - |
dc.contributor.author | Park, Kyoung Mii | - |
dc.contributor.author | Han, Dong-Jin | - |
dc.contributor.author | Bang, Nam Young | - |
dc.contributor.author | Kim, Do-Hee | - |
dc.contributor.author | Na, Hyeongjin | - |
dc.contributor.author | Lim, Semi | - |
dc.contributor.author | Kim, Tae Bum | - |
dc.contributor.author | Kim, Dae Gyu | - |
dc.contributor.author | Kim, Hyun-Jung | - |
dc.contributor.author | Chung, Yeonseok | - |
dc.contributor.author | Sung, Sang Hyun | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.contributor.author | Kim, Sunghoon | - |
dc.contributor.author | Han, Byung Woo | - |
dc.date.accessioned | 2021-01-31T09:21:26Z | - |
dc.date.available | 2021-01-31T09:21:26Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2015-11 | - |
dc.identifier.citation | PLoS ONE, Vol.10 No.11, p. e0142624 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.other | 783 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172599 | - |
dc.description.abstract | Despite the growing attention given to Traditional Medicine (TM) worldwide, there is no wellknown, publicly available, integrated bio-pharmacological Traditional Korean Medicine (TKM) database for researchers in drug discovery. In this study, we have constructed PharmDB-K, which offers comprehensive information relating to TKM-associated drugs (compound), disease indication, and protein relationships. To explore the underlying molecular interaction of TKM, we integrated fourteen different databases, six Pharmacopoeias, and literature, and established a massive bio-pharmacological network for TKM and experimentally validated some cases predicted from the PharmDB-K analyses. Currently, PharmDB-K contains information about 262 TKMs, 7,815 drugs, 3,721 diseases, 32,373 proteins, and 1,887 side effects. One of the unique sets of information in PharmDB-K includes 400 indicator compounds used for standardization of herbal medicine. Furthermore, we are operating PharmDB-K via phExplorer (a network visualization software) and BioMart (a data federation framework) for convenient search and analysis of the TKM network. Database URL: http://pharmdb-k.org, http://biomart.i-pharm.org. | - |
dc.language | 영어 | - |
dc.publisher | Public Library of Science | - |
dc.title | PharmDB-K: Integrated bio-pharmacological network database for traditional Korean medicine | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1371/journal.pone.0142624 | - |
dc.citation.journaltitle | PLoS ONE | - |
dc.identifier.wosid | 000364430700143 | - |
dc.identifier.scopusid | 2-s2.0-84953256520 | - |
dc.citation.number | 11 | - |
dc.citation.startpage | e0142624 | - |
dc.citation.volume | 10 | - |
dc.identifier.sci | 000364430700143 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Chung, Yeonseok | - |
dc.contributor.affiliatedAuthor | Sung, Sang Hyun | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.contributor.affiliatedAuthor | Kim, Sunghoon | - |
dc.contributor.affiliatedAuthor | Han, Byung Woo | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | COX-2 EXPRESSION | - |
dc.subject.keywordPlus | CHINESE MEDICINE | - |
dc.subject.keywordPlus | INFORMATION | - |
dc.subject.keywordPlus | UPDATE | - |
dc.subject.keywordPlus | SCHIZANDRIN | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | RESOURCE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CELLS | - |
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