Publications
Detailed Information
Amelioration of UVB-induced oxidative stress and inflammation in fat-1 transgenic mouse skin
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yum, Hye-Won | - |
dc.contributor.author | Kim, Seong Hoon | - |
dc.contributor.author | Kang, Jing X. | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T09:21:37Z | - |
dc.date.available | 2021-01-31T09:21:37Z | - |
dc.date.created | 2019-06-26 | - |
dc.date.issued | 2018-07-07 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications, Vol.502 No.1, pp.1-8 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | 76797 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172602 | - |
dc.description.abstract | omega-3 polyunsaturated fatty acids (PUFAs), which are abundant in fish oils, are known to scavenge lipid peroxyl radicals and potentiate host immune defence. As UVB-induced oxidative stress and inflammation have been implicated in apoptotic cell death, this study was aimed to investigate the anti-inflammatory, anti-oxidative, and anti-apoptotic capacity of fat-1 transgenic mice capable of converting omega-6 to omega-3 PUFAs. Wild-type (WT) C57BL/6 mice and fat-1 mice were maintained on the AIN-93 diet supplemented with 10% safflower oil rich in omega-6 PUFAs for 5 weeks. The omega-3/omega-6 PUFA ratio was significantly higher in the dorsal skin of fat-1 mice than that in the WT mice. Upon single exposure to UVB (5.0 kJ/m(2)) radiation, fat-1 mice showed inflammatory as well as oxidative tissue damage and the expression of proinflammatory enzymes, cyclooxygenases-2 and inducible nitric oxide synthase in the skin to a much lesser extent than the WT mice. The protection of fat-1 mice from UVB-induced skin inflammation was associated with decreased phosphorylation of STAT3. Moreover, UVB-induced apoptosis was attenuated in fat-1 mouse skin. In comparison to WT animals, higher levels of Nrf2 and its target proteins, such as heme oxygenase-1, NAD(P)H:quinone oxidoreductase-1 and thioredoxin-1, were found in the skin of fat1 mice. (C) 2018 Published by Elsevier Inc. | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | Amelioration of UVB-induced oxidative stress and inflammation in fat-1 transgenic mouse skin | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/j.bbrc.2018.05.093 | - |
dc.citation.journaltitle | Biochemical and Biophysical Research Communications | - |
dc.identifier.wosid | 000436383800001 | - |
dc.identifier.scopusid | 2-s2.0-85047421712 | - |
dc.citation.endpage | 8 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 1 | - |
dc.citation.volume | 502 | - |
dc.identifier.sci | 000436383800001 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | N-6 FATTY-ACIDS | - |
dc.subject.keywordPlus | HUMAN KERATINOCYTES | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | CARCINOGENESIS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordAuthor | fat-1 transgenic mice | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Mouse skin | - |
dc.subject.keywordAuthor | omega-3 polyunsaturated fatty acids | - |
dc.subject.keywordAuthor | Oxidative stress | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.