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15-Deoxy-Δ12,14-prostaglandin J2 rescues PC12 cells from H2O2-induced apoptosis through Nrf2-mediated upregulation of heme oxygenase-1: Potential roles of Akt and ERK1/2 : 15-Deoxy-delta(12,14)-prostaglandin J(2) rescues PC12 cells from H(2)O(2)-induced apoptosis through Nrf2-mediated upregulation of heme oxygenase-1: Potential roles of Akt and ERK1/2
DC Field | Value | Language |
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dc.contributor.author | Kim, Ji-Woo | - |
dc.contributor.author | Li, Mei-Hua | - |
dc.contributor.author | Jang, Jung-Hee | - |
dc.contributor.author | Na, Hye-Kyung | - |
dc.contributor.author | Song, Na-Young | - |
dc.contributor.author | Lee, Chan | - |
dc.contributor.author | Johnson, Jeffrey A. | - |
dc.contributor.author | Surh, Young-Joon | - |
dc.date.accessioned | 2021-01-31T09:21:58Z | - |
dc.date.available | 2021-01-31T09:21:58Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2008-12 | - |
dc.identifier.citation | Biochemical Pharmacology, Vol.76 No.11, pp.1577-1589 | - |
dc.identifier.issn | 0006-2952 | - |
dc.identifier.other | 3042 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172608 | - |
dc.description.abstract | Oxidative stress induced by reactive oxygen intermediates has been implicated in a variety of human diseases including rheumatoid arthritis and neuro degenerative disorders. 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), a terminal dehydration product of prostaglandin D(2), is an endogenous ligand of peroxisome proliferator-activated receptor-gamma and exhibits a number of biological activities including the proapoptotic activity. Recent studies have revealed that this cyclopentenone prostaglandin, at non-toxic concentrations, can also exert antiapoptotic or cytoprotective effects. In this study, the underlying mechanisms involved in the protective effects of 15d-PGJ(2) on the H(2)O(2)-induced cytotoxicty were explored using cultured rat pheochromocytoma (PC12) cells. PC12 cells treated with H(2)O(2) underwent apoptosis, which was attenuated by pretreatment with non-toxic concentrations of 15d-PGJ(2). Treatment of the PC12 cells with 15d-PGJ(2) resulted in increased nuclear translocation, DNA-binding and transcriptional activity of NF-E2-related factor 2 (Nrf2), leading to upregulation of heme oxygenase-1 (HO-1) expression, which provided an adaptive survival response against the H(2)O(2)-derived oxidative cytotoxicity. Transfection of PC12 cells with dominant-negative Nrf2 gene abolished the 15d-PGJ(2)-derived induction of HO-1 expression. Moreover, the 15d-PGJ(2)-mediated increases in Nrf2-ARE binding and ARE luciferase activity were suppressed by the dominant-negative mutation as well as the pharmacological inhibition of Akt/protein kinase B or extracellular signal-regulated kinase 1/2 (ERK1/2). Taken together, these findings suggest that 15d-PGJ(2) augments cellular antioxidant defense capacity through activation of Akt and ERK signal pathways that leads to Nrf2 activation, and subsequently HO-1 induction, thereby protecting the PC12 cells from H(2)O(2)-induced oxidative cell death. (c) 2008 Published by Elsevier Inc. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | 15-Deoxy-Δ12,14-prostaglandin J2 rescues PC12 cells from H2O2-induced apoptosis through Nrf2-mediated upregulation of heme oxygenase-1: Potential roles of Akt and ERK1/2 | - |
dc.title.alternative | 15-Deoxy-delta(12,14)-prostaglandin J(2) rescues PC12 cells from H(2)O(2)-induced apoptosis through Nrf2-mediated upregulation of heme oxygenase-1: Potential roles of Akt and ERK1/2 | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1016/j.bcp.2008.08.007 | - |
dc.citation.journaltitle | Biochemical Pharmacology | - |
dc.identifier.wosid | 000261569400028 | - |
dc.identifier.scopusid | 2-s2.0-55949091956 | - |
dc.citation.endpage | 1589 | - |
dc.citation.number | 11 | - |
dc.citation.startpage | 1577 | - |
dc.citation.volume | 76 | - |
dc.identifier.sci | 000261569400028 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young-Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | HUMAN NEUROBLASTOMA-CELLS | - |
dc.subject.keywordPlus | ACTIVATED-RECEPTOR-GAMMA | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR NRF2 | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | CYCLOPENTENONE PROSTAGLANDINS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | ADIPOCYTE DIFFERENTIATION | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | CARBON-MONOXIDE | - |
dc.subject.keywordPlus | GLUTATHIONE | - |
dc.subject.keywordAuthor | 15-Deoxy-Delta(12,14)-prostaglandin J(2) | - |
dc.subject.keywordAuthor | Heme oxygenase-1 | - |
dc.subject.keywordAuthor | Nrf2 | - |
dc.subject.keywordAuthor | Antioxidant response elements | - |
dc.subject.keywordAuthor | Cyclopentenone prostaglandin | - |
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