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Hepatic DNA and RNA adduct formation from the carcinogen 7-hydroxymethyl-12-methylbenz[a]anthracene and its electrophilic sulfuric acid ester metabolite in preweanling rats and mice

Cited 47 time in Web of Science Cited 57 time in Scopus
Authors

Surh, Young-Joon; Lai, Chen-Ching; Miller, James A.; Miller, Elizabeth C.

Issue Date
1987-04
Publisher
Academic Press
Citation
Biochemical and Biophysical Research Communications, Vol.144 No.2, pp.576-582
Abstract
DNA and RNA adducts that were chromatographically identical to those formed in vitro on reaction of 7-sulfooxymethyl-12-methyl-benz[a]anthracene with guanine and adenine nucleosides were formed in the livers of rats and mice given i.p. injections of 7-hydroxymethyl- or 7-sulfooxymethyl-12-methylbenz[a]anthracene. Considerably higher levels of these hepatic adducts were obtained from the latter short-lived electrophilic ester than from the hydroxymethyl compound. These observations are consistent with the finding of rat liver cytosolic sulfotransferase activity for 7-hydroxymethyl-12-methylbenz[a]-anthracene (Watabe et al., Science 215, 403, 1982). Formation of these hepatic adducts from 7-hydroxymethyl-12-methylbenz[a]anthracene was inhibited by prior administration to rats of dehydroepiandrosterone, an inhibitor of the sulfotransferase activity for this hydroxymethyl hydrocarbon. © 1987 Academic Press, Inc.
ISSN
0006-291X
URI
https://hdl.handle.net/10371/172614
DOI
https://doi.org/10.1016/S0006-291X(87)80005-0
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