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Potentiation of cellular antioxidant capacity by Bcl-2: implications for its antiapoptotic function

Cited 84 time in Web of Science Cited 91 time in Scopus
Authors
Jang, Jung-Hee; Surh, Young-Joon
Issue Date
2003-10
Citation
Biochemical Pharmacology, Vol.66 No.8, pp.1371-1379
Keywords
antioxidant enzymesbcl-2glutathionemitogen-activated protein kinasesNF-kappa Boxidative cell death
Abstract
A substantial body of data from clinical and laboratory studies indicates that reactive oxygen intermediates are implicated in the pathogenesis of diverse human diseases, including cancer, diabetes, and neurodegenerative disorders. Oxidative stress induced by reactive oxygen intermediates often causes cell death via apoptosis that is regulated by a plenty of functional genes and their protein products. Bcl-2, which is an integral intermitochondrial membrane protein, blocks apoptosis induced by a wide array of death signals. In spite of extensive research. the molecular milieu that characterizes the antiapoptotic function of Bcl-2 is complex and not fully identified. Recently, there are several lines of evidence that Bcl-2 functions via antioxidant pathways to prevent apoptosis. Thus, bcl-2-over-expressing cells exhibit elevated expression of antioxidant enzymes and higher levels of cellular GSH compared with the control cells transfected with the vector alone. There has been increasing evidence supporting that the redox-sensitive transcription factor nuclear factor kappaB regulates the activity and/or expression of antioxidative and antiapoptotic target genes and promotes cell survival against oxidative cell death. This commentary focuses on the antioxidative functions of Bcl-2 and underlying molecular mechanisms in relation to its antiapoptotic property. The role of Bcl-2 in regulation of nuclear factor kappaB signaling pathways and possible cross-talk with mitogen-activated protein kinases are also discussed. (C) 2003 Elsevier Inc. All rights reserved.
ISSN
0006-2952
URI
https://hdl.handle.net/10371/172620
DOI
https://doi.org/10.1016/S0006-2952(03)00487-8
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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