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Inhibitory effects of the standardized extract (DA‐9601) of Artemisia asiatica Nakai on phorbol ester–induced ornithine decarboxylase activity, papilloma formation, cyclooxygenase‐2 expression, inducible nitric oxide synthase expression and nuclear transcription factor κB activation in mouse skin

Cited 65 time in Web of Science Cited 65 time in Scopus
Authors
Seo, Hyo‐Joung; Park, Kwang‐Kyun; Han, Seong Su; Chung, Won‐Yoon; Son, Mi‐Won; Kim, Won‐Bae; Surh, Young‐Joon
Issue Date
2002-08
Citation
International Journal of Cancer, Vol.100 No.4, pp.456-462
Keywords
Artemisia asiaticaantitumor promotionantiinflammationcyclooxygenase-2DA-9601inducible nitric oxide synthaseNF-kappa Bornithine decarboxylase
Abstract
Artemisia asiatica Nakai has been used in traditional Asian medicine for the treatment of inflammatory and other disorders. Previous studies have revealed that the formulated ethanol extract (DA-9601) of A. asiatica has pronounced antioxidative and antiinflammatory activities and exhibits cytoprotective effects against experimentally induced gastrointestinal, hepatic and pancreatic damage. In the present study, we assessed the inhibitory effect of DA-9601 on tumor promotion, which is closely linked to inflammatory tissue damage. As an initial approach to evaluating the possible antitumor-promoting potential of DA-9601, its effects on TPA-induced ear edema were examined in female ICR mice. Pretreatment of the inner surface of the mouse ear with DA-9601 30 min prior to topical application of TPA inhibited ear edema at 5 hr. TPA-stimulated expression of epidermal COX-2 and NOS was also mitigated by topical application of the same extract. Moreover, DA-9601 abrogated the TPA-mediated activation of NF-kappaB/Rel and AP-I in mouse epidermis. Suppression of epidermal NF-kappaB by DA-9601 appeared to be mediated in part through inhibition of IkappaBalpha degradation, thereby blocking the nuclear translocation of p65, the functional subunit of NF-kappaB. DA-9601 also significantly suppressed TPA-induced ODC activity and papilloma formation in mouse skin. Taken together, these findings suggest that DA-9601 derived from A. asiatica possesses potential chemopreventive activities. (C) 2002 Wiley-Liss, Inc.
ISSN
0020-7136
URI
https://hdl.handle.net/10371/172629
DOI
https://doi.org/10.1002/ijc.10489
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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