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Transcription factors and mitogen-activated protein kinases as molecular targets for chemoprevention with anti-inflammatory phytochemicals

Cited 16 time in Web of Science Cited 16 time in Scopus
Authors

Surh, Young‐Joon; Na, Hye‐Kyung; Lee, Seung Sei

Issue Date
2004
Publisher
International Union of Biochemistry by IRL Press
Citation
BioFactors, Vol.21 No.1-4, pp.103-108
Abstract
Chemoprevention refers to the use of nontoxic chemical substances to inhibit, reverse, or retard tumorigenesis. Numerous compounds derived from edible plants have been reported to interfere with a specific stage of the carcinogenic process. Some anti-inflammatory phytochemicals with cyclooxygenase-2 inhibitory activity have been found to exert chemopreventive properties by targeting intracellular signaling molecules (recently reviewed by Y.J. Surh, Nature Reviews Cancer, 3: 768-780, 2003). These include mitogen-activated protein kinases and transcription factors, such as NF-kappaB and AP-1.
ISSN
0951-6433
URI
https://hdl.handle.net/10371/172633
DOI
https://doi.org/10.1002/biof.552210119
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College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
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