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Resveratrol inhibits phorbol ester-induced cyclooxygenase-2 expression in mouse skin: MAPKs and AP-1 as potential molecular targets
DC Field | Value | Language |
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dc.contributor.author | Kundu, Joydeb Kumar | - |
dc.contributor.author | Chun, Kyung‐Soo | - |
dc.contributor.author | Kim, Sue O. | - |
dc.contributor.author | Surh, Young‐Joon | - |
dc.date.accessioned | 2021-01-31T09:23:41Z | - |
dc.date.available | 2021-01-31T09:23:41Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | BioFactors, Vol.21 No.1-4, pp.33-39 | - |
dc.identifier.issn | 0951-6433 | - |
dc.identifier.other | 4289 | - |
dc.identifier.uri | https://hdl.handle.net/10371/172635 | - |
dc.description.abstract | Multiple lines of evidence from laboratory studies suggest that resveratrol, a polyphenolic antioxidant present in grapes, has potent chemopreventive activity. Resveratrol has been reported to inhibit chemically-induced carcinogenesis in mouse skin, but the underlying mechanisms remain unclarified. Since an abnormally elevated level of cyclooxygenase-2 (COX-2) has been implicated in carcinogenesis, we investigated the effect of resveratrol on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced COX-2 expression in mouse skin. Pretreatment of dorsal skin of female ICR mice with resveratrol inhibited TPA-induced COX-2 expression in a dose dependent manner. To elucidate the molecular mechanism underlying COX-2 inhibition by resveratrol, we examined its effect on TPA-induced activation of mitogen-activated protein kinases (MAPK) and transcription factors which regulate COX-2 expression. Resveratrol pretreatment resulted in a decrease in the phosphorylation of extracellular signal-regulated protein kinase (ERK) as well as the catalytic activity of ERK and p38 MAPK. In addition, resveratrol prevented TPA-induced DNA binding of activator protein-1 (AP-1). Taken together, suppression of COX-2 expression by blocking the activation of MAPKs and AP-1 may represent possible molecular mechanisms responsible for previously reported anti-tumor promoting effects of resveratrol on mouse skin carcinogenesis. | - |
dc.language | 영어 | - |
dc.publisher | International Union of Biochemistry by IRL Press | - |
dc.title | Resveratrol inhibits phorbol ester-induced cyclooxygenase-2 expression in mouse skin: MAPKs and AP-1 as potential molecular targets | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 서영준 | - |
dc.identifier.doi | 10.1002/biof.552210108 | - |
dc.citation.journaltitle | BioFactors | - |
dc.identifier.wosid | 000227306700008 | - |
dc.identifier.scopusid | 2-s2.0-16444382588 | - |
dc.citation.endpage | 39 | - |
dc.citation.number | 1-4 | - |
dc.citation.startpage | 33 | - |
dc.citation.volume | 21 | - |
dc.identifier.sci | 000227306700008 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Surh, Young‐Joon | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MAMMARY EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL REGULATION | - |
dc.subject.keywordPlus | ACTIVATOR PROTEIN-1 | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | COX-2 | - |
dc.subject.keywordPlus | CARCINOGENESIS | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | PHYTOCHEMICALS | - |
dc.subject.keywordAuthor | chemoprevention | - |
dc.subject.keywordAuthor | resveratrol | - |
dc.subject.keywordAuthor | cyclooxygenase-2 (COX-2) | - |
dc.subject.keywordAuthor | activator protein-1 | - |
dc.subject.keywordAuthor | mitogen-activated protein kinase (MAPK) | - |
dc.subject.keywordAuthor | mouse skin carcinogenesis | - |
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