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Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-κB and p38 MAPK in mouse skin

Cited 91 time in Web of Science Cited 103 time in Scopus
Authors
Kim, Sue Ok; Chun, Kyung‐Soo; Kundu, Joydeb Kumar; Surh, Young‐Joon
Issue Date
2004
Citation
BioFactors, Vol.21 No.1-4, pp.27-31
Keywords
chemopreventioncyclooxygenase-2[6]-gingerolp38 MAPKNF-kappa Bmouse skin
Abstract
[6]-Gingerol, a major pungent ingredient of ginger (Zingiber officinale Roscoe, Zingiberaceae), has a wide array of pharmacologic effects. Previous studies have demonstrated that [6]-gingerol inhibits mouse skin tumor promotion and anchorage-independent growth of cultured mouse epidermal cells stimulated with epidermal growth factor. Cyclooxygenase-2 (COX-2), a key enzyme in the prostaglandin biosynthesis, has been recognized as a molecular target for many anti-inflammatory as well as chemopreventive agents. Topical application of [6]-gingerol inhibited phorbol 12-myristate 13-acetate -induced COX-2 expression. One of the essential transcription factors responsible for COX-2 induction is NF-kappaB. [6]-Gingerol suppressed NF-kappaB DNA binding activity in mouse skin. In addition, [6]-gingerol inhibited the phoshorylation of p38 mitogen-activated protein kinase which may account for its inactivation of NF-kappaB and suppression of COX-2 expression.
ISSN
0951-6433
URI
https://hdl.handle.net/10371/172636
DOI
https://doi.org/10.1002/biof.552210107
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Journal Papers (저널논문_분자의학 및 바이오제약학과)
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