Browse

Inhibitory effects of curcumin and capsaicin on phorbol ester-induced activation of eukaryotic transcription factors, NF-κB and AP-1 : Inhibitory effects of curcumin and capsaicin on phorbol ester-induced activation of eukaryotic transcription factors, NF-kappa B and AP-1

Cited 88 time in Web of Science Cited 118 time in Scopus
Authors

Surh, Young‐Joon; Han, Seong Su; Keum, Young‐Sam; Seo, Hyo‐Joung; Lee, Sang Sup

Issue Date
2000-12
Publisher
International Union of Biochemistry by IRL Press
Citation
BioFactors, Vol.12 No.1-4, pp.107-112
Abstract
Recently, considerable attention has been focused on identifying dietary and medicinal phytochemicals that can inhibit, retard or reverse the multi-stage carcinogenesis. Spices and herbs contain phenolic substances with potent antioxidative and chemopreventive properties. Curcumin, a yellow colouring agent from turmeric and capsaicin, a pungent principle of red pepper exhibit profound anticarcinogenic and antimutagenic activities. Two well-defined eukaryotic transcription factors. nuclear factor-kappa B (NF-kappaB) and activator protein 1 (AP-1) have been implicated in pathogenesis of many human diseases including cancer. These transcription factors are known to be activated by a wide array of external sri mull, such as tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). tumor necrosis factor, reactive oxy gen species, bacterial lipopolysaccharide, acid ultraviolet. In the present study, we found that topical application of TPA onto dorsal skin of female ICR mice resulted in marked activation of epidermal NF-kappaB and AP-1. Curcumin and capsaicin, when topically applied prior to TPA, significantly attenuated TPA-induced activation of each transcription factor in mouse skin. Likewise, both compounds inhibited NF-kappaB and AP-1 activation in cultured human promyelocytic leukemia (HL-60) cells stimulated with TPA. Based on these findings, it is likely that curcumin and capsaicin exert anti-tumor promotional effects through suppression of the tumor promoter-induced activation of transcription factors, NF-kappaB and AP-1.
ISSN
0951-6433
URI
https://hdl.handle.net/10371/172637
DOI
https://doi.org/10.1002/biof.5520120117
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Journal Papers (저널논문_약학과)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse